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Review
. 2019 Mar;38(3):423-426.
doi: 10.1007/s10096-018-3429-x. Epub 2018 Nov 15.

Alternative switching strategies based on regimens with a low genetic barrier: do clinicians have a choice nowadays?

Jesús Troya  1   2 , Pablo Ryan  3   4 , Rocío Montejano  5 , Alfonso Cabello  6 , Guillermo Cuevas  3 , Mariano Matarranz  3 , Irene Cañamares  3 , Javier Solís  3 , Luis Álvarez-Sala Walther  4   7
Affiliations
Review

Alternative switching strategies based on regimens with a low genetic barrier: do clinicians have a choice nowadays?

Jesús Troya et al. Eur J Clin Microbiol Infect Dis. 2019 Mar.

Abstract

Clinicians sometimes use switching strategies based on regimens such as RAL + ABC/3TC or RPV + ABC/3TC in order to resolve tolerability or safety issues associated with conventional recommended first-line strategies. Despite the low genetic barrier of these regimens, high safety and efficacy rates have been reported in retrospective studies.

Keywords: Abacavir/lamivudine; Efficacy; Raltegravir; Rilpivirine; Safety; Switching.

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References

    1. J Infect Dis. 2004 Mar 15;189(6):1056-74 - PubMed
    1. AIDS. 2010 Jul 17;24(11):1697-707 - PubMed
    1. Clin Infect Dis. 2010 Oct 15;51(8):963-72 - PubMed
    1. Drug Metab Dispos. 2011 Jun;39(6):1070-8 - PubMed
    1. PLoS One. 2012;7(3):e32445 - PubMed

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