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Meta-Analysis
. 2018 Nov 16;13(11):e0207725.
doi: 10.1371/journal.pone.0207725. eCollection 2018.

Sequential organ failure assessment in predicting mortality after paraquat poisoning: A meta-analysis

Wen Jie Wang  1 , Li Wei Zhang  2 , Shun Yi Feng  1 , Jie Gao  1 , Yong Li  1
Affiliations
Meta-Analysis

Sequential organ failure assessment in predicting mortality after paraquat poisoning: A meta-analysis

Wen Jie Wang et al. PLoS One. .

Abstract

Sequential organ failure assessment (SOFA) score is commonly used to determine disease severity and predict prognosis in critically ill patients. However, the prognostic value of SOFA after acute paraquat (PQ) poisoning remains unclear. This meta-analysis aimed to study the capability of SOFA to predict mortality in patients with PQ poisoning. Databases that included PubMed, Embase, Web of Science, ScienceDirect, Embase, and Cochrane Library were searched through May 2018. Six studies involving 946 patients were included in the meta-analysis. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and then ORs with 95% CIs were pooled for the estimation of the prognostic role of SOFA in patients with PQ poisoning. Results showed that higher SOFA in patients with PQ poisoning was related to severe mortality (OR = 8.14, 95%CI 4.26-15.58, p<0.001). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic OR, and area under the curve were 72% (95%CI 0.65-0.79), 75% (95%CI 0.65-0.83), 2.9 (95%CI 2.0-4.1), 0.37 (95%CI 0.28-0.41), 8 (95%CI 4-14), and 0.79 (95%CI 0.76-0.83), respectively. No evidence of publication bias was detected by funnel plot analysis and formal statistical tests. Sensitivity analyses showed no important differences in the estimates of effects. The high SOFA score (8.1-fold) was associated with severe mortality in patients with PQ poisoning.

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Conflict of interest statement

The authors have declared no competing interests exist.

Figures

Fig 1
Fig 1. Risk of bias and applicability concerns.
Fig 2
Fig 2. Forest plot for the association of SOFA and mortality.
Fig 3
Fig 3. Risk of bias and applicability concerns.
Fig 4
Fig 4. Summary ROC curve for the 6 included studies.
Numbers in brackets are 95% CIs. AUC = area under ROC curve, SENS = sensitivity, SPEC = specificity.
Fig 5
Fig 5. Funnel plot of the publication bias test.
(A)Begg’s test; and (B) Egger’s test.
Fig 6
Fig 6. Sensitivity analysis of the relationship between SOFA and mortality.
See this image and copyright information in PMC

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