Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Nov 15;175(5):1175-1176.
doi: 10.1016/j.cell.2018.10.060.

Flaviviruses Hit a Moving Target

Jonathan Braun  1
Affiliations
Comment

Flaviviruses Hit a Moving Target

Jonathan Braun. Cell. .

Abstract

The enteric nervous system (ENS) is central to intestinal motility and a candidate target for the heterogeneous spectrum of dysmotility diseases. White et al. reveal that relapsing intestinal dysmotility occurs when partial ENS depletion by enteric neurotropic viruses is followed by functional impairment due to intermittent nonspecific intestinal inflammation.

PubMed Disclaimer

Conflict of interest statement

DECLARATION OF INTERESTS

J.B. declares scientific advisory board member roles for Janssen, Allergan, Pro-lacta Bioscience, and UBiome.

Figures

Figure 1.
Figure 1.. Infection and Intestinal Motility
Intestinal dysmotility can happen as an acute viral infection or post infection in the presence of inflammatory mediators.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Bamias G, Corridoni D, Pizarro TT, and Cominelli F (2012). New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation. Cytokine 59, 451–459. - PMC - PubMed
    1. Chavan SS, and Tracey KJ (2017). Essential Neuroscience in Immunology. J. Immunol 198, 3389–3397. - PMC - PubMed
    1. Furness JB (2012). The enteric nervous system and neurogastroenterology. Nat. Rev. Gastroenterol. Hepatol 9, 286–294. - PubMed
    1. Klem F, Wadhwa A, Prokop LJ, Sundt WJ, Farrugia G, Camilleri M, Singh S, and Grover M (2017). Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis. Gastroenterology 152, 1042–1054.e1. - PMC - PubMed
    1. Mayer EA, Tillisch K, and Gupta A (2015). Gut/brain axis and the microbiota. J. Clin. Invest 125, 926–938. - PMC - PubMed

Publication types