A State-of-the-Art Review of New and Emerging Therapies for the Treatment of IBD

Abstract

Over the last 2 decades, novel therapies targeting several immune pathways have been developed for the treatment of patients with inflammatory bowel disease (IBD). Although anti-tumor necrosis factor (anti-TNF) agents remain the firstline treatment for moderate to severe Crohn's disease and ulcerative colitis, many patients will require alternative agents, due to nonresponse, loss of response, or intolerance of anti-TNFs. Furthermore, patients may request newer therapies due to improved safety profiles or improved administration (ie, less frequent injection, oral therapy). This review will focus on new and emerging therapies for the treatment of IBD, with a special focus on their adverse effects. Although many of the agents included in this paper have been approved for use in IBD, a few are still in development but have been shown to be effective in phase II clinical trials. 10.1093/ibd/izy327_video1 izy327.video1 5967364908001.

Keywords: Crohn’s disease; biological therapy; inflammatory bowel disease; safety; stem cells; ulcerative colitis.

FIGURE 1.

Novel therapy targets in the treatment of IBD. Reprinted from Trends in Pharmacological Sciences, Volume 38 (2), Mehmet Coskun, Severine Vermeire, Ole Haagen Nielsen, Novel Targeted Therapies for Inflammatory Bowel Disease, Pages 127–142, 2017, with permission from Elsevier.