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Review
. 2019 Jan;13(1):99-109.
doi: 10.1002/term.2772. Epub 2018 Dec 13.

Macrophage functions in wound healing

Malgorzata Kloc  1   2   3 , Rafik M Ghobrial  1   2 , Jarek Wosik  4   5 , Aneta Lewicka  6 , Sławomir Lewicki  7 , Jacek Z Kubiak  7   8
Affiliations
Free article
Review

Macrophage functions in wound healing

Malgorzata Kloc et al. J Tissue Eng Regen Med. 2019 Jan.
Free article

Abstract

Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

Keywords: CX3CR1; ROCK kinase; RhoAactin; macrophages; wound healing.

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