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Comment
. 2018 Nov 16;6(1):120.
doi: 10.1186/s40425-018-0443-6.

Immune checkpoint inhibitor-related acral vasculitis

Thibault Comont  1 , Vincent Sibaud  2 , Loïc Mourey  3 , Pierre Cougoul  4 , Odile Beyne-Rauzy  4
Affiliations
Comment

Immune checkpoint inhibitor-related acral vasculitis

Thibault Comont et al. J Immunother Cancer. .

Abstract

Commentary on « Ipilimumab induced vasculitis » by Padda A. et al., J Immunother Cancer. 2018;6:12. The authors diagnosed a small vessel vasculitis following treatment with anti-CTLA-4 (ipilimumab) for a resected stage III B/C melanoma. We report a similar case of acral vasculitis occurring with a combination of anti-CTLA-4 (tremelimumab) and anti-PD-L1 (durvalumab) prescribed for the management of a metastatic urothelial bladder cancer. In contrast to Padda A. et al., we observed a significant improvement with oral corticosteroids.

Keywords: Immune check point inhibitors; Immune-related adverse events; Vasculitis.

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Conflict of interest statement

Ethics approval and consent to participate

No formal ethics approval was needed since we were only reporting an observational case report. Consent was obtained from the patient.

Consent for publication

Consent was obtained from the patient. He signed a biomed generic consent for this journal.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Digital lesions upon diagnosis of small vessel vasculitis (a), 1 month after initiation of corticosteroids (b) and at a one-year follow-up (c)
See this image and copyright information in PMC

Comment on

  • Ipilimumab induced digital vasculitis.
    Padda A, Schiopu E, Sovich J, Ma V, Alva A, Fecher L. Padda A, et al. J Immunother Cancer. 2018 Feb 12;6(1):12. doi: 10.1186/s40425-018-0321-2. J Immunother Cancer. 2018. PMID: 29433584 Free PMC article.

References

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