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Review
. 2018 Dec;39(12):1004-1007.
doi: 10.1016/j.tips.2018.09.008. Epub 2018 Nov 13.

Geroneuroprotectors: Effective Geroprotectors for the Brain

David Schubert  1 , Antonio Currais  1 , Joshua Goldberg  1 , Kim Finley  2 , Michael Petrascheck  3 , Pamela Maher  4
Affiliations
Review

Geroneuroprotectors: Effective Geroprotectors for the Brain

David Schubert et al. Trends Pharmacol Sci. 2018 Dec.

Abstract

Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.

Keywords: Alzheimer’s disease; aging; drug discovery; geroscience; multimorbidity; neuroprotection.

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Figures

Figure 1.
Figure 1.. Geroneuroprotectors (GNPs) Share Molecular Pathways with Caloric Restriction and Geroprotectors.
Heatmap of molecular pathways activated (shown as red) or inhibited (shown as blue) by the different compounds is shown. White spaces denote that the effects were not determined whereas the hatched boxes depict publications showing both activation and inhibition. Data are compiled from [,,–20].
See this image and copyright information in PMC

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