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Comment
. 2018 Dec 3;150(12):1599-1601.
doi: 10.1085/jgp.201812251. Epub 2018 Nov 16.

Oddballs in the Shaker family: Kv2-related regulatory subunits

William R Kobertz  1
Affiliations
Comment

Oddballs in the Shaker family: Kv2-related regulatory subunits

William R Kobertz. J Gen Physiol. .

Abstract

Kobertz comments on the family of “silent” Kv2-related regulatory subunits and a new study investigating their assembly idiosyncrasies.

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Figures

Figure 1.
Figure 1.
Shaker family domains and regions that influence 3:1R and 2:2R heterotetramer formation. (A) The self-incompatible T1 hypothesis. T1 domains from Kv2-related regulatory subunits (Kv5.1, Kv6.1–6.4, Kv8.1–8.2 and Kv9.1–9.3) are hypothesized to be self-incompatible because they do not exit the ER and traffic to the cell surface. The cartoon shows (boxed) the potential Kv2 heterotetramers that could form based on the self-incompatible T1 hypothesis. (B) S6 consensus sequence logos generated by Pisupati et al. (2018) for Shaker-like Kv family subunits that form functional homotetrameric channels and the Kv2-related regulatory subunits from mouse Kv6, Kv8, and Kv9 subunits.
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References

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