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Comment
. 2018 Nov 27;115(48):12092-12094.
doi: 10.1073/pnas.1817485115. Epub 2018 Nov 16.

Phosphatidylserine hide-and-seek

Suzanne Cory  1   2
Affiliations
Comment

Phosphatidylserine hide-and-seek

Suzanne Cory. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Phospholipid redistribution dynamics at the plasma membrane. (A) In normal cells, flippases ATP11A and ATP11C, heterodimerized with their chaperone, CDC50A, continuously translocate PtdSer from the outer to the inner leaflet of the plasma membrane (unidirectional gray arrow), and the scramblases XKR8 and TMEM16F are inactive. (B) In cells undergoing apoptosis, caspase-3 cleavage irreversibly inactivates ATP11A/11C. In addition, caspase-3 cleaves XKR8, and the truncated XKR8, together with either basigin (BSG) or neuroplastin (NPTN), undergoes dimerization and bidirectionally translocates phospholipids (bidirectional gray arrow). (C) In cells undergoing Ca2+-mediated activation, TMEM16F is stabilized by Ca2+ binding, dimerizes, and scrambles phospholipids (bidirectional gray arrow), and the flippases are probably transiently inactivated. (D) Engulfment by phagocytic cells of apoptotic cell bodies or live cells exposing PtdSer. A, N, and P refer to the actuator, nucleotide-binding, and phosphorylation domains of the cytoplasmic region of ATP11A/C. (Further details are provided in the main text and in ref. .) Adapted with permission from Annual Reviews, from ref. and from ref. , with permission from Elsevier. Permission conveyed through Copyright Clearance Center, Inc.
See this image and copyright information in PMC

Comment on

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