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. 2019 Jan;21(1):3-17.
doi: 10.1007/s12094-018-1978-1. Epub 2018 Nov 17.

SEOM clinical guidelines for the treatment of non-small cell lung cancer (2018)

M Majem  1 , O Juan  2 , A Insa  3 , N Reguart  4 , J M Trigo  5 , E Carcereny  6 , R García-Campelo  7 , Y García  8 , M Guirado  9 , M Provencio  10
Affiliations

SEOM clinical guidelines for the treatment of non-small cell lung cancer (2018)

M Majem et al. Clin Transl Oncol. 2019 Jan.

Abstract

Non-small cell lung cancer (NSCLC) accounts for up to 85% of all lung cancers. The last few years have seen the development of a new staging system, diagnostic procedures such as liquid biopsy, treatments like immunotherapy, as well as deeper molecular knowledge; so, more options can be offered to patients with driver mutations. Groups with specific treatments account for around 25% and demonstrate significant increases in overall survival, and in some subgroups, it is important to evaluate each treatment alternative in accordance with scientific evidence, and even more so with immunotherapy. New treatments similarly mean that we must reconsider what should be done in oligometastatic disease where local treatment attains greater value.

Keywords: Chemotherapy; Immunotherapy; NSCLC; Radiotherapy; Targeted therapies.

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Conflict of interest statement

Conflict of interest

MM reports personal fees from AstraZeneca, Roche, Lilly, Bristol-Myers Squibb, Pfizer, Boehringer Ingelheim, Novartis, Tesaro, outside the submitted work. OJ reports grants from Astra Zeneca and personal fees from Astra Zeneca, BMS, MSD, ROCHE, Boehringer Ingelheim, Lilly outside the submitted work. MP reports grants from BMS, Roche and personal fees from BMS, MSD, ROCHE, Pierre Fabre, Novartis; Takeda, Lilly, Pfizer outside the submitted work. NR reports advisory Board/Consultancy/Speaker honoraria from MSD, Bristol-Myers, Roche, Boehringer Ingelheim, Guardant Health, Pfizer, Abbie, Ipsen, Novartis, Astra-Zeneca, Lilly, Takeda outside the submitted work; Research Funding from Pfizer, NanoString Technology, and Institutional financial interests related to clinical trials and patient recruitment. GC reports non-financial support from Millennium Pharmaceuticals, Inc., during the conduct of the study; personal fees from ARIAD, AstraZeneca, Roche, Pfizer, BMS, Boehringer Ingelheim, MSD outside the submitted work. YG reports personal fees from Roche, Boehriger-ingelheim, Lilly, MSD, Pfizer, BMS outside the submitted work. JMT reports personal fees from Roche, Boehriger-ingelheim, BMS, Astra Zeneca, MerckSerono outside the submitted work. AI, EC, MG, have not reported any potential conflicts of interest.

Ethical approval

The current study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

No informed consent was necessary for this guideline.

Figures

Fig. 1
Fig. 1
Treatment algorithm for Stage III
Fig. 2
Fig. 2
Treatment algorithm for Stage IV with no targetable alterations
Fig. 3
Fig. 3
Treatment algorithm for Stage IV with known targetable drivers
See this image and copyright information in PMC

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