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Review
. 2019 Jan:661:145-148.
doi: 10.1016/j.abb.2018.11.011. Epub 2018 Nov 14.

Myocardial relaxation in human heart failure: Why sarcomere kinetics should be center-stage

Paul M L Janssen  1
Affiliations
Review

Myocardial relaxation in human heart failure: Why sarcomere kinetics should be center-stage

Paul M L Janssen. Arch Biochem Biophys. 2019 Jan.

Abstract

Myocardial relaxation is critical for the heart to allow for adequate filling of the ventricles prior to the next contraction. In human heart failure, impairment of myocardial relaxation is a major problem, and impacts most patients suffering from end-stage failure. Furthering our understanding of myocardial relaxation is critical in developing future treatment strategies. This review highlights processes involved in myocardial relaxation, as well as governing processes that modulate myocardial relaxation, with a focus on impairment of myocardium-level relaxation in human end-stage heart failure.

Keywords: Calcium; Contraction; Heart disease; Myofilaments.

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