Why did the sham-treated EPISOD study subjects do so well? Important lessons for research and practice

Affiliations

Comment

Peter B Cotton. Gastrointest Endosc. 2019 May.

. 2019 May;89(5):1054-1055.

doi: 10.1016/j.gie.2018.11.006. Epub 2018 Nov 14.

¹ Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina, USA.

No abstract available

Comment on

Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy: the EPISOD randomized clinical trial.
Cotton PB, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnasky P, Aliperti G, Freeman M, Kozarek R, Jamidar P, Wilcox M, Serrano J, Brawman-Mintzer O, Elta G, Mauldin P, Thornhill A, Hawes R, Wood-Williams A, Orrell K, Drossman D, Robuck P. Cotton PB, et al. JAMA. 2014 May;311(20):2101-9. doi: 10.1001/jama.2014.5220. JAMA. 2014. PMID: 24867013 Free PMC article. Clinical Trial.

1. Cotton PB, Durkalski V, Romagnuolo J, et al. Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on painrelated disability following cholecystectomy: the EPISOD randomized clinical trial. JAMA 2014;311:2101–9. - PMC - PubMed
1. Cotton PB, Pauls Q, Keith J, et al. The EPISOD study: long-term outcomes. Gastrointest Endosc 2018;87:205–210. - PubMed
1. Kaptchuk TJ, Miller FG. Placebo Effects in Medicine. N Engl J Med 2015;373:8–9. - PubMed
1. Jonas WB, Crawford C, Colloca L, Kaptchuk TJ, Moseley B, Miller FG, Kriston L, Linde K, Meissner K. To what extent are surgery and invasive procedures effective beyond a placebo response? A systematic review with metaanalysis of randomized, sham controlled trials. BMJ Open 2015;5:e009655. - PMC - PubMed
1. Meissner K, Bingel U, Colloca L et al. The Placebo Effect: Advances from Different Methodological Approaches. Journal of Neuroscience 2011;31:16117–16124 - PMC - PubMed