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Meta-Analysis
. 2018 Nov 17;18(1):172.
doi: 10.1186/s12871-018-0631-4.

Higher PEEP improves outcomes in ARDS patients with clinically objective positive oxygenation response to PEEP: a systematic review and meta-analysis

Lanqi Guo  1 , Jianfeng Xie  1 , Yingzi Huang  1 , Chun Pan  1 , Yi Yang  1 , Haibo Qiu  1 , Ling Liu  2
Affiliations
Meta-Analysis

Higher PEEP improves outcomes in ARDS patients with clinically objective positive oxygenation response to PEEP: a systematic review and meta-analysis

Lanqi Guo et al. BMC Anesthesiol. .

Abstract

Background: Mortality in patients with acute respiratory distress syndrome (ARDS) remains high. These patients require mechanical ventilation strategies that include high positive end-expiratory pressure (PEEP). It remains controversial whether high PEEP can improve outcomes for ARDS patients, especially patients who show improvement in oxygenation in response to PEEP. In this meta-analysis, we aimed to evaluate the effects of high PEEP on ARDS patients.

Methods: We electronically searched randomized controlled trials (RCTs) reported in the MEDLINE, CENTRAL, EMBASE, CINAHL and Web of Science databases from January 1990 to December 2017. Meta-analyses of the effects of PEEP on survival in adults with ARDS were conducted using the methods recommended by the Cochrane Collaboration.

Results: A total of 3612 patients from nine randomized controlled trials (RCTs) were included. There were 1794 and 1818 patients in the high and low PEEP groups, respectively. Hospital mortality showed no significant difference between the high and low PEEP groups (RR = 0.92; 95% CI, 0.79 to 1.07; P = 0.26). Similar results were found for 28-d mortality (RR = 0.88; 95% CI, 0.72 to 1.07; P = 0.19) and ICU mortality (RR = 0.83; 95% CI, 0.65 to 1.07; P = 0.15). The risk of clinically objectified barotrauma was not significantly different between the high and low PEEP groups (RR = 1.24; 95% CI, 0.74 to 2.09, P = 0.41). In the subgroup of ARDS patients who responded to increased PEEP by improved oxygenation (from 6 RCTs), high PEEP significantly reduced hospital mortality (RR = 0.83; 95% CI 0.69 to 0.98; P = 0.03), ICU mortality (RR = 0.74; 95% CI, 0.56 to 0.98; P = 0.04),but the 28-d mortality was not decreased(RR = 0.83; 95% CI, 0.67 to 1.01; P = 0.07). For ARDS patients in the low PEEP group who received a PEEP level lower than 10 cmH2O (from 6 RCTs), ICU mortality was lower in the high PEEP group than the low PEEP group (RR = 0.65; 95% CI, 0.45 to 0.94; P = 0.02).

Conclusions: For ARDS patients who responded to increased PEEP by improved oxygenation, high PEEP could reduce hospital mortality, ICU mortality and 28-d mortality. High PEEP does not increase the risk of clinically objectified barotrauma.

Keywords: ARDS; Barotrauma; Meta; Mortality; PEEP.

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Cochrane risk of bias assessment for mortality outcome
Fig. 2
Fig. 2
Study flow diagram
Fig. 3
Fig. 3
Effect of high PEEP on hospital mortality in ARDS patients with or without positive oxygenation response to PEEP
Fig. 4
Fig. 4
Effect of high PEEP on hospital mortality while the PEEP level of patients in low PEEP group was different
Fig. 5
Fig. 5
Effect of high PEEP on hospital mortality of moderate and severe ARDS patients between high and low PEEP groups
Fig. 6
Fig. 6
Effect of high PEEP on 28-day mortality in ARDS patients
Fig. 7
Fig. 7
Effect of high PEEP on 28-day mortality while the PEEP level of patients in low PEEP group was different
Fig. 8
Fig. 8
Effect of high PEEP on ICU mortality in ARDS patients
Fig. 9
Fig. 9
Effect of high PEEP on ICU mortality while the PEEP level of patients in low PEEP group was different
Fig. 10
Fig. 10
Effect of high PEEP on clinically objectified barotrauma in ARDS patients
See this image and copyright information in PMC

References

    1. Esteban Andrés, Ferguson Niall D., Meade Maureen O., Frutos-Vivar Fernando, Apezteguia Carlos, Brochard Laurent, Raymondos Konstantinos, Nin Nicolas, Hurtado Javier, Tomicic Vinko, González Marco, Elizalde José, Nightingale Peter, Abroug Fekri, Pelosi Paolo, Arabi Yaseen, Moreno Rui, Jibaja Manuel, D'Empaire Gabriel, Sandi Fredi, Matamis Dimitros, Montañez Ana María, Anzueto Antonio. Evolution of Mechanical Ventilation in Response to Clinical Research. American Journal of Respiratory and Critical Care Medicine. 2008;177(2):170–177. doi: 10.1164/rccm.200706-893OC. - DOI - PubMed
    1. Gattinoni L, Caironi P, Cressoni M, et al. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med. 2006;354:1775–1786. doi: 10.1056/NEJMoa052052. - DOI - PubMed
    1. Brower RG, Lanken PN, Mac Intyre N, et al. Higher versus lower positive end expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351:327–336. doi: 10.1056/NEJMoa032193. - DOI - PubMed
    1. Gattinoni L, Caironi P. Refining ventilatory treatment for acute lung injury and acute respiratory distress syndrome. JAMA. 2008;299(6):691–693. doi: 10.1001/jama.299.6.691. - DOI - PubMed
    1. Meade MO, Cook DJ, Guyatt GH, et al. Lung open ventilation study investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299:637–645. doi: 10.1001/jama.299.6.637. - DOI - PubMed

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