Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan;35(1):151-168.
doi: 10.1016/j.ccc.2018.08.004.

Infectious Complications Following Solid Organ Transplantation

Alexis Guenette  1 , Shahid Husain  2
Affiliations
Review

Infectious Complications Following Solid Organ Transplantation

Alexis Guenette et al. Crit Care Clin. 2019 Jan.

Abstract

Infections in solid organ transplant recipients are complex and heterogeneous. This article reviews the clinical syndromes that will likely be encountered in the intensive care unit and helps to guide in the therapy and management of these patients.

Keywords: Critical care; Infections; Intensive care unit (ICU); Sepsis; Solid organ transplant.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Timeline of common infections in SOT.
Fig. 2
Fig. 2
Treatment recommendations for RNA respiratory viruses in SOT recipients. IL-2, interleukin-2; IVIG, intravenous immunoglobulin; MoAb, monoclonal antibody.
Fig. 3
Fig. 3
CMV serostatus and the risk of complications.
Fig. 4
Fig. 4
Treatment of invasive fungal infections in SOT recipients.
Fig. 5
Fig. 5
Infectious causes of pulmonary complications in SOT recipients. RSV, respiratory syncytial virus.
Fig. 6
Fig. 6
Infectious causes of CNS and peripheral nervous system infections in SOT recipients. EBV, Epstein-Barr virus; LCMV, lymphocytic choriomeningitis virus; PTLD, posttransplant lymphoproliferative disease.
Fig. 7
Fig. 7
Infectious causes of hepatitis in SOT recipients. HIV, human immunodeficiency virus; PJP, pneumocystis jirovecii pneumonia; TB, tuberculosis; WNV, West Nile virus.
Fig. 8
Fig. 8
Infectious causes of diarrhea in SOT recipients. DAEC, Diffusely adherent Escherichia coli; EAEC, Enteroaggregative Escherichia coli; EIEC, Enteroinvasive Escherichia coli; EPEC, Enteropathogenic Escherichia coli; ETEC, Enterotoxigenic Escherichia coli; HHV6, Human Herpesvirus 6; STEC, Shiga toxin-producing E. coli.
See this image and copyright information in PMC

References

    1. Fernández-Ruiz M., Kumar D., Humar A. Clinical immune-monitoring strategies for predicting infection risk in solid organ transplantation. Clin Transl Immunology. 2014;3(2):e12. - PMC - PubMed
    1. Fishman J.A. From the classic concepts to modern practice. Clin Microbiol Infect. 2014;20(Suppl 7):4–9. - PubMed
    1. Berenger B.M., Doucette K., Smith S.W. Epidemiology and risk factors for nosocomial bloodstream infections in solid organ transplants over a 10-year period. Transpl Infect Dis. 2016;18(2):183–190. - PubMed
    1. Moreno A., Cervera C., Gavalda J., et al. Bloodstream infections among transplant recipients: results of a nationwide surveillance in Spain. Am J Transplant. 2007;7(11):2579–2586. - PubMed
    1. Sanroman Budino B., Vazquez Martul E., Pertega Diaz S., et al. Autopsy-determined causes of death in solid organ transplant recipients. Transplant Proc. 2004;36(3):787–789. - PubMed