RETRACTED: Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Panels from Figure 1B appear similar to panels from Figure 2B of the article that Yantao Han, Qian Zhao, Jie Zhou and Rui Shi have published in the American Journal of Cancer Research 7 (2017) 218-233 https://pubmed.ncbi.nlm.nih.gov/28337372/. Also, panel sections within Figure 5D appear similar to each other. Panel ‘AIF(25mg/kg)’ from Figure 7A appears similar to panel ‘His (20mg/kg)’ from Figure 8A of the article that Mei Han, Hui Gao, Ping Ju, Ming-quan Gao, Yin-ping Yuan, Xue-hong Chen, Kai-li Liu, Yan-tao Han and Zhi-wu Han have published in Biomedicine & Pharmacotherapy 103 (2018) 272-283 https://doi.org/10.1016/j.biopha.2018.04.014. Panels from Figure 7D appear similar to panels from Figure 6D of the article that Qiang Wang, Yi Yan, Jie Zhang, Peng Guo, Yuqing Xing, Yong Wang, Fawei Qin and Qingyun Zeng have published in Biomedicine & Pharmacotherapy 104 (2018) 28-35 https://doi.org/10.1016/j.biopha.2018.05.013, Figure 6C of the article that Xiao-ping Pan, Chen Wang, Yan Li and Li-hua Huang have published in Biomedicine & Pharmacotherapy 99 (2018) 894-903 https://doi.org/10.1016/j.biopha.2018.01.148 and Figure 4C of the article that Shufang Wei and Weiyuan Ma have published in Biomedicine & Pharmacotherapy 90 (2017) 278-286 https://doi.org/10.1016/j.biopha.2017.03.068. Panels from Figure 7F appear similar to panels from Figure 6F of the article that Xuezhu Lin, Mingquan Gao, Ailing Zhang, Jingjie Tong, Xiaoyi Zhang, Quanzhong Su, Zhihong Yang, Hui Gao and Guohui Jiang in Life Sciences 239 (2019) 117074 https://doi.org/10.1016/j.lfs.2019.117074, Figure 6F of the article that Luping Wang, Lu Yun, Xiaojun Wang, Liying Sha, Luning Wang, Yingying Sui and Hui Zhang have published in Life Sciences 218 (2019) 16-24 https://doi.org/10.1016/j.lfs.2018.12.023 and Figure 7H of the article that Ying Niu, Jinping Zhang, Yalin Tong, Jiansheng Li and Bingrong Liu have published in Life Sciences 237 (2019) 116893 https://doi.org/10.1016/j.lfs.2019.116893.

Keywords: Alpinumisoflavone; CRC; DNA-strand break; RAD51; γ-H2AX.