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. 2019 Sep;17(10):2129-2131.
doi: 10.1016/j.cgh.2018.11.006. Epub 2018 Nov 15.

Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas

Anna E Coghill  1 , Andrew M Bellizzi  2 , Charles F Lynch  3 , Meredith S Shiels  4 , Freda R Selk  5 , Maura Gillison  6 , Brenda Y Hernandez  7 , Owen T M Chan  7 , Eric A Engels  4
Affiliations

Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas

Anna E Coghill et al. Clin Gastroenterol Hepatol. 2019 Sep.

Abstract

Rectal squamous cell carcinoma (SCC) is a rare tumor with unresolved etiology. Human immunodeficiency virus-infected individuals and solid organ transplant recipients experience >30-fold and approximately 3-fold elevated rates of rectal SCC, respectively, suggesting immunosuppression plays a role.1 Human immunodeficiency virus-infected homosexual men have >60-fold higher rates of rectal SCC, similar to anal SCC. These patterns, which differ from the more common rectal adenocarcinoma (AdCA), raise the possibility of shared etiology between rectal and anal SCC, with human papillomavirus type 16 (HPV16) being a likely candidate.2.

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Conflict of interest statement

Disclosure: No authors report any conflicts of interest.

Figures

Figure 1.
Figure 1.
Example cases of anal SCC, rectal SCC, and rectal AdCa evaluated in this study. Hematoxylin and eosin (H&E) and p40 immunohistochemistry (clone BC28, Biocare, Pacheco CA) were used to confirm squamous vs. non-squamous histology. CAM5.2 immunohistochemistry (clone Cam5.2, Ventana Medical Systems, Tucson AZ) marks low molecular weight cytokeratins present in epithelial cells of the rectum but not the anus and was used to confirm tumor location.
See this image and copyright information in PMC

References

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