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. 2019 Sep;17(10):2132-2133.
doi: 10.1016/j.cgh.2018.11.008. Epub 2018 Nov 15.

Prevalence and Severity of Nonalcoholic Fatty Liver Disease Among Caregivers of Patients With Nonalcoholic Fatty Liver Disease Cirrhosis

Mohammad Shadab Siddiqui  1 , Salvatore Carbone  2 , Robert Vincent  1 , Samarth Patel  1 , Carolyn Driscoll  1 , Francesco S Celi  3 , Hayley Billingsley  2 , Brando Rotelli  2 , Binu John  4 , Nicola Potere  2 , Michele Viscusi  2 , Veronica Adiletta  2 , Arun J Sanyal  1 , Velimir A Luketic  1 , Trevor Reichman  5 , Chandra S Bhati  6
Affiliations

Prevalence and Severity of Nonalcoholic Fatty Liver Disease Among Caregivers of Patients With Nonalcoholic Fatty Liver Disease Cirrhosis

Mohammad Shadab Siddiqui et al. Clin Gastroenterol Hepatol. 2019 Sep.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting nearly 1 in 3 Americans.1 Nonalcoholic steatohepatitis (NASH), the clinically aggressive variant of NAFLD, has a propensity of fibrosis progression and increased risk of cirrhosis and hepatocellular carcinoma. NASH-related cirrhosis is now the most rapidly growing indication for liver transplantation (LT).2 Disease recurrence and progression to advanced fibrosis after LT are high3; however, the key contributors of these are unknown. We hypothesized that patients with NASH cirrhosis reside in a microenvironment conducive to not only development of NASH but also fibrosis progression, which likely persist after LT and contribute to disease recurrence. The hypothesis was tested by performing vibration-controlled transient elastography (VCTE) in primary caregivers and cohabitants of patients with decompensated cirrhosis awaiting LT.

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Conflict of interest statement

Conflicts of interest

The authors disclose no conflicts.

Figures

Figure 1.
Figure 1.
Controlled attenuation parameter (CAP) in caregivers of patients with NAFLD cirrhosis.
See this image and copyright information in PMC

References

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