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. 2018 Oct 12:9:92.
doi: 10.4103/ijpvm.IJPVM_312_17. eCollection 2018.

Preventive Effect of Hydroalcoholic Extract of Rosa damascena on Cardiovascular Parameters in Acute Hypertensive Rats Induced by Angiotensin II

Maryam Rahimi  1 , Mina Ghoreshi  1 , Bahman Emami  1 , Mohammad Naser Shafei  2 , Mahmoud Hosseini  3 , Abolfazl Khajavirad  1   2
Affiliations

Preventive Effect of Hydroalcoholic Extract of Rosa damascena on Cardiovascular Parameters in Acute Hypertensive Rats Induced by Angiotensin II

Maryam Rahimi et al. Int J Prev Med. .

Abstract

Background: Rosa damascena (R.D) is an aromatic plant with numerous therapeutic effects including cardiovascular effect. The mechanism cardiovascular effect of R.D is unclear and suggested mediated through renin-angiotensin system (RAS). Therefore, in this study, the role of hydroalcoholic extract of R.D on acute hypertension induced by AngII was evaluated.

Methods: After anesthesia, femoral artery and vein of rats were cannulated for recording cardiovascular responses and drug injection, respectively. Systolic blood pressure (SBP), mean arterial blood pressure (MAP), and heart rate (HR) were recorded continuously by power lab software. Rats were divided into saline, AngII (50 ng/kg), AngII + Losartan (10 mg/kg), and three groups of R.D extract (250, 500, and 1000 mg/kg). Losartan and AngII were administered intravenously and the other ones intraperitoneal. In the R.D groups, 30 min after injection of the extract, AngII was injected and the maximum changes in SBP, MAP, and HR were calculated and compared to that in control and AngII groups.

Results: Results show that AngII significantly increased SBP, MAP, and decreased HR than the control group which was blocked by losartan. SBP and MAP in R.D + AngII groups were significantly lower than AngII alone (P < 0.05 -P < 0.001). Only MAP in higher dose (1000 mg/kg) was significantly lower than low dose (250 mg/kg; P < 0.05). Two higher doses also significantly decreased bradycardia induced by AngII (P < 0. 01).

Conclusions: The preventive effect of hydroalcoholic extract of R.D on cardiovascular parameters maybe is mediated by suppression of AngII activity.

Keywords: Angiotensin II; Rosa damascena; blood pressure; heart rate; rennin–angiotensin system.

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Conflict of interest statement

There are no conflicts of interest

Figures

Figure 1
Figure 1
Effects of angiotensin II (50 ng/kg; intravenous) and angiotensin II + losartan (10mg/kg) on SBP (a) MAP (b), and HR (c) in anesthetized rats. Data were expressed as a mean ± standard error of the mean. One-way ANOVA used for statistical analysis. (n = 7) ***P < 0.001 compare to control +++P < 0.001; compare to angiotensin II group #: P < 0.05 Los + angiotensin II compare to control SBP = systolic blood pressure, MAP: mean arterial blood pressure, HR = heart rate
Figure 2
Figure 2
Effects of hydroalcoholic extract of Rosa damascena on changes of systolic blood pressure in anesthetized rats. Three doses of extract (250, 500, and 1000 mg/kg) injected (intraperitoneally) after 30 min angiotensin II injected and changes of systolic blood pressure determined. Data were expressed as a mean ± standard error of the mean. One-way ANOVA used for statistical analysis (n = 7). *: P < 0.01, **: P < 0.01, and ***: P < 0.001 compared to angiotensin II +: P < 0.01 dose 250 compared to angiotensin II + Los
Figure 3
Figure 3
Effects of hydroalcoholic extract of Rosa damascena on changes of mean arterial blood pressure in anesthetized rats. Three doses of extract (250, 500, and 1000 mg/kg) injected (intraperitoneally) after 30 min angiotensin II injected and cardiovascular responses determined. Data were expressed as a mean ± standard error of the mean. One-way ANOVA used for statistical analysis (n = 7). **: P < 0.01 and ***: P < 0.001 compare to angiotensin II + P < 0.05, ++; P < 0.01 compared to angiotensin II + Los
Figure 4
Figure 4
Effects of hydroalcoholic extract of Rosa damascena on changes of heart rate in anesthetized rats. Three doses of extract (250, 500, and 1000 mg/kg) injected (intraperitoneally) after 30 min angiotensin II injected and cardiovascular responses determined. Data were expressed as a mean ± standard error of the mean. One-way ANOVA used for statistical analysis. (n = 7) *; P < 0.01 compare to angiotensin II + P < 0.05 compare to angiotensin II + Los
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