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. 2018 Nov;48(6):395-404.
doi: 10.4041/kjod.2018.48.6.395. Epub 2018 Sep 14.

Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

Shifat A Nowrin  1 , Saidi Jaafar  2 , Norma Ab Rahman  1 , Rehana Basri  3 , Mohammad Khursheed Alam  4 , Fazal Shahid  1
Affiliations

Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

Shifat A Nowrin et al. Korean J Orthod. 2018 Nov.

Abstract

Objective: To date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR.

Methods: A complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017.

Results: On the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment.

Conclusions: More research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.

Keywords: Evidence-based orthodontics; Genetics; Root resorption; Tooth movement.

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Conflict of interest statement

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Flow chart of the PRISMA guidelines for study selection.
Figure 2
Figure 2. Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CC vs. TT). OR, Odds ratio; 95% CI, 95% confidence interval.
Figure 3
Figure 3. Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CT vs. TT). OR, Odds ratio; 95% CI, 95% confidence interval.
Figure 4
Figure 4. Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CC+CT vs. TT). OR, Odds ratio; 95% CI, 95% confidence interval.
Figure 5
Figure 5. Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CC vs. CT+TT). OR, Odds ratio; 95% CI, 95% confidence interval.
Figure 6
Figure 6. Funnel plot for the publication bias test (CT vs. TT).
See this image and copyright information in PMC

References

    1. Wehrbein H, Fuhrmann RA, Diedrich PR. Human histologic tissue response after long-term orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 1995;107:360–371. - PubMed
    1. Parker RJ, Harris EF. Directions of orthodontic tooth movements associated with external apical root resorption of the maxillary central incisor. Am J Orthod Dentofacial Orthop. 1998;114:677–683. - PubMed
    1. Brezniak N, Wasserstein A. Orthodontically induced inflammatory root resorption. Part I: the basic science aspects. Angle Orthod. 2002;72:175–179. - PubMed
    1. Harris EF, Kineret SE, Tolley EA. A heritable component for external apical root resorption in patients treated orthodontically. Am J Orthod Dentofacial Orthop. 1997;111:301–309. - PubMed
    1. Al-Qawasmi RA, Hartsfield JK, Jr, Everett ET, Flury L, Liu L, Foroud TM, et al. Genetic predisposition to external apical root resorption. Am J Orthod Dentofacial Orthop. 2003;123:242–252. - PubMed

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