Experimental rodent models of chronic prostatitis and evaluation criteria

Abstract

Chronic prostatitis (CP) is a common disease in urology and can be develop in all age groups. It is more commonly seen in men over the age of 50. It's cure rate is low, the recurrence rate is high, the symptoms are complicated, the duration of disease is prolonged, the lingering is difficult to heal, the pain site is extensive and the associated symptoms are more, which bring great physical pain and mental burden to the patient. At present, the etiology, pathology and pathophysiology of prostatitis are not clear yet, and it is still a difficult problem in medical research. The establishment of an effective animal model for experimental research has become an important way to explore its pathogenesis. There are currently several popular modeling methods that vary in degree of operation, success rate, and time length. It would become a trend to study chronic prostatitis through different modeling methods in the future. The successful preparation of animal models can provide the treatment of CP with the corresponding theoretical basis. This article reviews the recent advances in research on rodent models and analyzes the advantages, limitations, and evaluation criteria of various models for reference.

Keywords: Animal model; Autoimmunity; Chronic abacterial prostatitis; Chronic prostatitis; Model evaluation index; Modeling method; Pelvic pain.