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Review
. 2018 Oct;43(19):3828-3833.
doi: 10.19540/j.cnki.cjcmm.20180726.017.

[Research progress on in vitro and in vivo behaviors of poorly soluble Chinese materia medica nanosuspension]

[Article in Chinese]
Bao-de Shen  1   2 , Cheng-Ying Shen  2 , Ling-Xia Xu  1 , Wei-Feng Zhu  1 , Hai-Long Yuan  2
Affiliations
Review

[Research progress on in vitro and in vivo behaviors of poorly soluble Chinese materia medica nanosuspension]

[Article in Chinese]
Bao-de Shen et al. Zhongguo Zhong Yao Za Zhi. 2018 Oct.

Abstract

Nanosuspension (also called nanocrystal suspension or nanocrystal) could significantly enhance the saturated solubility and dissolution of insoluble drugs, and improve their bioavailability by reducing particle size and increasing the specific surface, which could then solve the delivery problems of the poorly soluble active ingredients and effective parts of Chinese materia medica (CMM). Based on the brief summaries of nanosuspension preparation methods, this paper would mainly review the in vitro and in vivo behaviors of poorly soluble CMM nanosuspension, discuss and analyze its problems, so as to provide reference and thinking for the further study of nanosuspension drug delivery system of poorly soluble CMM and promote the development and perfection of nanosuspension technology in CMM.

Keywords: Chinese materia medica; in vitro/vivo behavior; nanosuspension; preparation method; research progress.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.