Recent advancement in nanocarriers for oral vaccination

Abstract

Non-invasive mucosal immune response plays an important role in controlling various infections through mucosal route. Therefore, the appropriate induction of effective immune response should be elicited after immunization. Currently, a lot of strategies have been investigated to enhance the mucosal immunity including microparticles, liposomes, virosomes, cochleates and aracheosomes. These carriers due to tunable and unique physicochemical properties offer the possibility for better antigen presentation by appropriate cells, being more effective to induce a comparable immune response. The objective of this review is to give an overview of novel strategies for the delivery of vaccines through the mucosal route.

Keywords: Mucosal vaccines; aracheosomes; cochleates; liposomes; microparticles; virosomes.