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Comment
. 2018 Nov 20;16(1):212.
doi: 10.1186/s12916-018-1210-8.

How does malaria in pregnancy impact malaria risk in infants?

Prasanna Jagannathan  1
Affiliations
Comment

How does malaria in pregnancy impact malaria risk in infants?

Prasanna Jagannathan. BMC Med. .

Abstract

Malaria in pregnancy not only exerts profound negative consequences on the health of the mother and developing fetus, but may also alter the risk of malaria during infancy. Although mechanisms driving this altered risk remain unclear, in utero exposure to malaria antigens may impact the development of fetal and infant innate immunity. In an article in BMC Medicine, Natama et al. describe an ambitious analysis of basal and TLR-stimulated cord blood responses among a birth cohort in Burkina Faso. Basal levels of several cytokines, chemokines, and growth factors were shown to be significantly lower in cord blood with histopathologic evidence of placental malaria. Additionally, following TLR7/8 stimulation, samples obtained from infants of mothers with placental malaria were hyper-responsive compared to those without evidence of prenatal malaria exposure. Furthermore, several responses impacted by placental malaria were associated with differential malaria risk in infancy. Understanding how malaria in pregnancy shapes immune responses in infants will provide critical insight into the rational design of malaria control strategies during pregnancy, including intermittent preventative treatment in pregnancy and vaccines.Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1187-3.

Keywords: Malaria; TLR stimulation; cord blood; innate immunity; malaria in pregnancy.

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References

    1. Walker PG, ter Kuile FO, Garske T, Menendez C, Ghani AC. Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study. Lancet Glob Health. 2014;2(8):e460–e467. doi: 10.1016/S2214-109X(14)70256-6. - DOI - PubMed
    1. Le Hesran JY, Cot M, Personne P, Fievet N, Dubois B, Beyeme M, Boudin C, Deloron P. Maternal placental infection with Plasmodium falciparum and malaria morbidity during the first 2 years of life. Am J Epidemiol. 1997;146(10):826–831. doi: 10.1093/oxfordjournals.aje.a009200. - DOI - PubMed
    1. Mutabingwa TK, Bolla MC, Li JL, Domingo GJ, Li X, Fried M, Duffy PE. Maternal malaria and gravidity interact to modify infant susceptibility to malaria. PLoS Med. 2005;2(12):e407. doi: 10.1371/journal.pmed.0020407. - DOI - PMC - PubMed
    1. Schwarz NG, Adegnika AA, Breitling LP, Gabor J, Agnandji ST, Newman RD, Lell B, Issifou S, Yazdanbakhsh M, Luty AJ, et al. Placental malaria increases malaria risk in the first 30 months of life. Clin Infect Dis. 2008;47(8):1017–1025. doi: 10.1086/591968. - DOI - PubMed
    1. Bardaji A, Sigauque B, Sanz S, Maixenchs M, Ordi J, Aponte JJ, Mabunda S, Alonso PL, Menendez C. Impact of malaria at the end of pregnancy on infant mortality and morbidity. J Infect Dis. 2011;203(5):691–699. doi: 10.1093/infdis/jiq049. - DOI - PMC - PubMed