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. 2018 Nov 19;16(1):315.
doi: 10.1186/s12967-018-1691-4.

Associations of immunological factors with metabolic syndrome and its characteristic elements in Chinese centenarians

Shihui Fu  1   2 , Yao Yao  3   4 , Faqin Lv  5 , Fu Zhang  6 , Yali Zhao  7 , Fuxin Luan  8
Affiliations

Associations of immunological factors with metabolic syndrome and its characteristic elements in Chinese centenarians

Shihui Fu et al. J Transl Med. .

Abstract

Background: Metabolic syndrome (MetS) has an increased prevalence (approximately 20-25% of the adult population) all over the world. Immunological function is significantly associated with the development of MetS, and MetS is beginning to be considered as a chronic immune-related disease. The present study addressed on the associations of immunological factors with MetS and its characteristic elements in Chinese centenarians.

Methods: Hainan is a longevity region with the highest population density of centenarians in China. The China Hainan Centenarian Cohort Study has a considerable sample size, and provides a significant population-based sample of centenarians. Home interview, physical examination and blood analysis were conducted following standard procedures.

Results: All centenarians had a median age of 102 (100-115) years, and the proportion of females was 80.8%. The proportion of centenarians with MetS was 16.0% (135 centenarians). Abdominal obesity, hypertension, dyslipidemia and diabetes mellitus had a prevalence of 26.4% (223 centenarians), 73.7% (623 centenarians), 40.4% (341 centenarians) and 10.7% (90 centenarians), respectively. In Logistic regression analyses, MetS was significantly associated with immunoglobulin E and complement C3 levels (P < 0.05 for all). Abdominal obesity was significantly associated with immunoglobulin E and complement C3 levels (P < 0.05 for all).

Conclusions: The present study provides epidemiological evidence that MetS has significant associations with immunoglobulin E and complement C3 levels, and demonstrates that abdominal obesity is significantly associated with immunoglobulin E and complement C3 levels in Chinese centenarians.

Keywords: Abdominal obesity; Chinese centenarians; Complement C3; Immunoglobulin E; Metabolic syndrome.

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Figures

Fig. 1
Fig. 1
Complement C3 and immunoglobulin E levels of centenarians with and without metabolic syndrome
See this image and copyright information in PMC

References

    1. Aguilar M, Bhuket T, Torres S, Liu B, Wong RJ. Prevalence of the metabolic syndrome in the United States, 2003–2012. JAMA. 2015;313(19):1973–1974. doi: 10.1001/jama.2015.4260. - DOI - PubMed
    1. Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2010;375(9710):181–183. doi: 10.1016/S0140-6736(09)61794-3. - DOI - PubMed
    1. Liu Z, Tang Q, Wen J, Tang Y, Huang D, Huang Y, Xie J, Luo Y, Liang M, Wu C, Lu Z, Tan A, Gao Y, Wang Q, Jiang Y, Yao Z, Lin X, Zhang H, Mo Z, Yang X. Elevated serum complement factors 3 and 4 are strong inflammatory markers of the metabolic syndrome development: a longitudinal cohort study. Sci Rep. 2016;6:18713. doi: 10.1038/srep18713. - DOI - PMC - PubMed
    1. Kastorini CM, Panagiotakos DB, Georgousopoulou EN, Laskaris A, Skourlis N, Zana A, Chatzinikolaou C, Chrysohoou C, Puddu PE, Tousoulis D, Stefanadis C, Pitsavos C, ATTICA Study Group Metabolic syndrome and 10-year cardiovascular disease incidence: the ATTICA study. Nutr Metab Cardiovasc Dis. 2016;26(3):223–231. doi: 10.1016/j.numecd.2015.12.010. - DOI - PubMed
    1. Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract. 2014;2014:943162. - PMC - PubMed

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