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Review
. 1988;5(3):145-51.
doi: 10.1007/BF02986437.

Mechanisms of cellular resistance to cisplatin

G A Hospers  1 , N H Mulder, E G De Vries
Affiliations
Review

Mechanisms of cellular resistance to cisplatin

G A Hospers et al. Med Oncol Tumor Pharmacother. 1988.

Abstract

Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistance in vitro and in vivo are presented.

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References

    1. Biochemistry. 1986 Aug 12;25(16):4534-9 - PubMed
    1. J Histochem Cytochem. 1983 Feb;31(2):307-17 - PubMed
    1. Cancer Treat Rep. 1983 Jul-Aug;67(7-8):641-6 - PubMed
    1. Nature. 1981 Nov 19;294(5838):281-3 - PubMed
    1. Biochem Pharmacol. 1986 Oct 1;35(19):3283-91 - PubMed