Peripheral and central determinants of skin wetness sensing in humans

Abstract

Evolutionarily, our ability to sense skin wetness and humidity (i.e., hygroreception) could have developed as a way of helping to maintain thermal homeostasis, as much as it is the case for the role of temperature sensation and thermoreception. Humans are not provided with a specific skin hygroreceptor, and recent studies have indicated that skin wetness is likely to be centrally processed as a result of the multisensory integration of peripheral inputs from skin thermoreceptors and mechanoreceptors coding the biophysical interactions between skin and moisture. The existence of a specific hygrosensation strategy for human wetness perception has been proposed and the first neurophysiologic model of skin wetness sensing has been recently developed. However, while these recent findings have shed light on some of the peripheral and central neural mechanisms underlying wetness sensing, our understanding of how the brain processes the thermal and mechanical inputs that give rise to one of our "most worn" skin sensory experiences is still far from being conclusive. Understanding these neural mechanisms is clinically relevant in the context of those neurologic conditions that are accompanied by somatosensory abnormalities. The present chapter will present the current knowledge on the peripheral and central determinants of skin wetness sensing in humans.

Keywords: body temperature; mechanoreceptors; skin; somatosensory disorders; thermoreceptors; wetness.