Lupus Nephritis

Abstract

Childhood-onset systemic lupus erythematosus (SLE) is a subset of SLE with an onset before 18 years of age. Patients with early onset SLE tend to have a greater genetic component to their disease cause, more multisystemic involvement, and a more severe disease course, which includes greater risks for developing nephritis and end-stage kidney disease. Five- and 10-year mortality is lower than in adult-onset SLE. Although patient and renal survival have improved with advances in induction and maintenance immunosuppression, accumulation of irreversible damage is common. Cardiovascular and infectious complications are frequent, as are relapses during adolescence and the transition to adulthood.

Trial registration: ClinicalTrials.gov NCT01946880.

Keywords: Autoantibody; Biopsy; Complement; Glomerulopathy; Hematuria; Lupus; Nephritis; Proteinuria.