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. 2019 Jan 29;63(2):e01384-18.
doi: 10.1128/AAC.01384-18. Print 2019 Feb.

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort

George R Thompson 3rd  1   2 , Charles R Krois  3 , Verena K Affolter  4 , Angela D Everett  5 , E Katarina Varjonen  5 , Victoria R Sharon  6 , Anil Singapuri  7 , Michael Dennis  7 , Ian McHardy  7 , Hong Sik Yoo  3 , Dawn M Fedor  3 , Nathan P Wiederhold  8 , Phylicia A Aaron  9 , Angie Gelli  9 , Joseph L Napoli  3 , Stephen D White  5
Affiliations

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort

George R Thompson 3rd et al. Antimicrob Agents Chemother. .

Abstract

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

Keywords: alopecia; antifungal; fluconazole; side effect.

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Figures

FIG 1
FIG 1
Percentage of hair in telogen phase over time in fluconazole-treated and nontreated animals.
FIG 2
FIG 2
Serum and skin levels of atRA, retinyl esters, and retinol. *, Statistical significance. P values are noted over groups where differences are apparent.
See this image and copyright information in PMC

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