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. 2018 Oct 21;6(10):1857-1861.
doi: 10.3889/oamjms.2018.333. eCollection 2018 Oct 25.

Comparison of the Effects of Omega 3 and Vitamin E on Palcitaxel-Induced Peripheral Neuropathy

Ali Arash Anoushirvani  1 , Laila Poorsaadat  2 , Reza Aghabozorgi  1 , Maryam Kasravi  3
Affiliations

Comparison of the Effects of Omega 3 and Vitamin E on Palcitaxel-Induced Peripheral Neuropathy

Ali Arash Anoushirvani et al. Open Access Maced J Med Sci. .

Abstract

Background: Paclitaxel-induced peripheral neuropathy is the most important side effect limiting the use of this medication.

Aim: This study aimed to compare the effects of omega-3 and vitamin E on the incidence of peripheral neuropathy in patients receiving Taxol.

Methods: In this clinical trial, 63 patients who were a candidate for receiving taxol, were enrolled based on inclusion and exclusion criteria. In group O, patients received 640 mg omega-3 three times a day, and group E, received 300 mg vitamin E two times a day. Patients took the supplements up to three months after the onset of Taxol. Group P received placebo for a similar period. All patients referred to a neurologist for electrophysiological evaluation before the onset of chemotherapy and at months 1 and 3. The presence of neuropathy and its progression was recorded by the neurologist.

Results: Neurological examination in this study indicated that 6 patients (28.6%) in Group O, 7 patients (33.3%) in group E, and 15 patients (71.4%) in placebo group started peripheral neuropathy. There was a significant difference between intervention groups and the placebo group (p = 0.0001) and no significant difference between intervention groups (p = 0.751).

Conclusion: Our data suggested that vitamin E and omega-3 may significantly reduce the incidence of Paclitaxel-induced peripheral neuropathy. Routine administration of such supplements that have no special side effect for patients under chemotherapy may greatly enhance their quality of life.

Keywords: Neuropathy; Omega 3; Paclitaxel; Vitamin E.

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Figures

Figure 1
Figure 1
Frequency of sex in three groups
Figure 2
Figure 2
The mean age (± standard deviation) of patients in three groups of malignancy
Figure 3
Figure 3
Malignancy in three groups
Figure 4
Figure 4
The incidence and severity of peripheral neuropathy in the three groups
See this image and copyright information in PMC

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