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. 2018 Oct 23;6(10):1862-1867.
doi: 10.3889/oamjms.2018.365. eCollection 2018 Oct 25.

Comparison of Dexmedetomidine and Fentanyl as an Adjuvant to Lidocaine 5% for Spinal Anesthesia in Women Candidate for Elective Caesarean

Alireza Kamali  1 , Ronak Azadfar  2 , Shirin Pazuki  1 , Maryam Shokrpour  3
Affiliations

Comparison of Dexmedetomidine and Fentanyl as an Adjuvant to Lidocaine 5% for Spinal Anesthesia in Women Candidate for Elective Caesarean

Alireza Kamali et al. Open Access Maced J Med Sci. .

Abstract

Aim: This study aimed to compare the effect of Dexmedetomidine and fentanyl as an adjuvant to lidocaine 5% in spinal anaesthesia to increase post-operative analgesia among women candidates for elective caesarean.

Methods: Eighty-four pregnant women candidates for caesarian were randomly divided into fentanyl and Dexmedetomidine groups. In the first group, 25 μg fentanyl was added to lidocaine 5% while in the second group, 0.5 μg per kilogram Dexmedetomidine was added to lidocaine 5%. After the operation, a pain score of the patients in recovery and within 4, 12 and 24 hours after the operation, the average length of analgesia and the average amount of the analgesics taken within 24 hours and after the operation were recorded.

Results: The average length of postoperative anaesthesia and the average amount of the drug taken within the first 24 hours after the operation in fentanyl group was more than the Dexmedetomidine group (P = 0.01). Shivering in Dexmedetomidine group was more common than what was observed in the fentanyl group (P = 0.001). Higher rates of nausea-vomiting were observed in the fentanyl group (P = 0.001).

Conclusions: Fentanyl results in a longer period of postoperative analgesia and less consumption of drugs after the operation. Fentanyl is recommended in caesarian.

Keywords: Dexmedetomidine; Fentanyl; Lidocaine; Pain; Spinal Anesthesia.

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Figure 1
Figure 1
A) Comparing the average postoperative analgesic time; B) The average amount of drug taken within 24 hours after an operation by patients candidate for caesarean using spinal anaesthesia in both groups
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