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Case Reports
. 2018 Oct 12;6(11):2240-2245.
doi: 10.1002/ccr3.1859. eCollection 2018 Nov.

Severe cholestatic jaundice associated with Graves' disease

Abebe Abebe  1 , Leigh M Eck  2 , Michael Holyoak  1
Affiliations
Case Reports

Severe cholestatic jaundice associated with Graves' disease

Abebe Abebe et al. Clin Case Rep. .

Abstract

We describe a rare case of Graves' disease presenting with atrial fibrillation and severe cholestasis. An extensive evaluation for hepatobiliary causes of cholestasis, including hepatic biopsy, was entirely negative. He was successfully treated with methimazole and eventual thyroidectomy. With caution, thionamides can be utilized successfully for such patients.

Keywords: Graves’ disease; cholestatic jaundice; hyperthyroidism; thyrotoxicosis.

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Figures

Figure 1
Figure 1
Transaminases and bilirubin changes prior to and while on treatment
Figure 2
Figure 2
Free thyroxine changes prior to and during therapy
See this image and copyright information in PMC

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