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Case Reports
. 2018 Nov 12;4(10):1052-1054.
doi: 10.1016/j.jdcr.2018.07.010. eCollection 2018 Nov.

Eruptive melanocytic nevi associated with ponatinib

Inès Devred  1 , Jean-Philippe Arnault  1 , Alanoud Adas  1 , Delphine Rea  2 , Florian Lombart  1 , Henri Sevestre  3 , Stèphanie Trudel  4 , Catherine Lok  1 , Guillaume Chaby  1
Affiliations
Case Reports

Eruptive melanocytic nevi associated with ponatinib

Inès Devred et al. JAAD Case Rep. .
No abstract available

Keywords: ALL, acute lymphoblastic leukemia; CML, chronic myeloid leukemia; EMN, eruptive melanocytic nevi; Ph+, Philadelphia chromosome–positive; TKI, tyrosine kinase inhibitor; adverse effects; chronic myeloid leukemia; drugs; eruptive melanocytic nevi; ponatinib.

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Figures

Fig 1
Fig 1
Small uniform brown nevi on the thigh.
Fig 2
Fig 2
Dermatoscopic view of nevi shows regular ring-shaped structure.
Fig 3
Fig 3
Histologic evaluation of the lesions found melanocytic proliferation at the basal layer of the epidermis, sometimes forming a small nest. (Hematoxylin-eosin-safran stain; original magnification: ×400.)
See this image and copyright information in PMC

References

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    1. Alloo A., Sheu J., Butrynski J.E. Ponatinib-induced pityriasiform, folliculocentric and ichthyosiform cutaneous toxicities. Br J Dermatol. 2015;173:574–577. - PubMed
    1. Hutchinson J. Outbreak of a large crop of moles. Remarks as to possible connection with melanosis. J Cutan Med Dis Skin. 1868;1:170–171.
    1. Perry B.M., Nguyen A., Desmond B.L., Blattner C.M., Thomas R.S., Young R.J. Eruptive nevi associated with medications (ENAMs) J Am Acad Dermatol. 2016;75:1045–1052. - PubMed
    1. Boussemart L., Routier E., Mateus C. Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients. Ann Oncol Off J Eur Soc Med Oncol. 2013;24:1691–1697. - PubMed

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