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Comparative Study
. 2019 Oct;24(10):1064-1076.
doi: 10.1111/nep.13531. Epub 2019 Apr 29.

International comparison of trends in patients commencing renal replacement therapy by primary renal disease

Vianda S Stel  1 , Ryan Awadhpersad  1 , Maria Pippias  1 , Manuel Ferrer-Alamar  2 , Patrik Finne  3   4 , Simon D Fraser  5 , James G Heaf  6 , Marc H Hemmelder  7 , Alberto Martínez-Castelao  8 , Johan de Meester  9 , Runolfur Palsson  10   11 , Friedrich C Prischl  12 , Mårten Segelmark  13 , Jamie P Traynor  14 , Rafael Santamaria  15 , Anna Varberg Reisaeter  16 , Ziad A Massy  17   18 , Kitty J Jager  1
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Free article
Comparative Study

International comparison of trends in patients commencing renal replacement therapy by primary renal disease

Vianda S Stel et al. Nephrology (Carlton). 2019 Oct.
Free article

Abstract

Aim: To examine international time trends in the incidence of renal replacement therapy (RRT) for end-stage renal disease (ESRD) by primary renal disease (PRD).

Methods: Renal registries reporting on patients starting RRT per million population for ESRD by PRD from 2005 to 2014, were identified by internet search and literature review. The average annual percentage change (AAPC) with a 95% confidence interval (CI) of the time trends was computed using Joinpoint regression.

Results: There was a significant decrease in the incidence of RRT for ESRD due to diabetes mellitus (DM) in Europe (AAPC = -0.9; 95%CI -1.3; -0.5) and to hypertension/renal vascular disease (HT/RVD) in Australia (AAPC = -1.8; 95%CI -3.3; -0.3), Canada (AAPC = -2.9; 95%CI -4.4; -1.5) and Europe (AAPC = -1.1; 95%CI -2.1; -0.0). A decrease or stabilization was observed for glomerulonephritis in all regions and for autosomal dominant polycystic kidney disease (ADPKD) in all regions except for Malaysia and the Republic of Korea. An increase of 5.2-16.3% was observed for DM, HT/RVD and ADPKD in Malaysia and the Republic of Korea.

Conclusion: Large international differences exist in the trends in incidence of RRT by primary renal disease. Mapping of these international trends is the first step in defining the causes and successful preventative measures of CKD.

Keywords: diabetes mellitus; hypertension; primary renal disease; renal replacement therapy; trends; worldwide.

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References

REFERENCES

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