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Case Reports
. 2019 Jan;100(1):78-80.
doi: 10.4269/ajtmh.18-0651.

Case Report: Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting

Shuwei Zheng  1 , Kwan Ki Karrie Ko  2 , Kian Sing Chan  3 , Indumathi Venkatachalam  1
Affiliations
Case Reports

Case Report: Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting

Shuwei Zheng et al. Am J Trop Med Hyg. 2019 Jan.

Abstract

In high prevalence settings, cryptosporidiosis is commonly implicated as a cause of a gastroenteritis syndrome in the organ transplant population. Stool microscopy is predominant diagnostic modality. Therapeutic options in this group of patients are limited, making their management exceptionally challenging. We describe a case of a renal transplant recipient with cryptosporidiosis confirmed by the stool FilmArray gastrointestinal panel (GIP) nucleic acid-based assay and stool microscopy, describe our institutional experience in diagnosing cryptosporidiosis in a low-prevalence setting, and review the available literature on management of this condition in the organ transplant population. In a low-prevalence setting, the GIP can serve as a rapid screening tool in the diagnosis of cryptosporidiosis.

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Figures

Figure 1.
Figure 1.
(A) Modified acid-fast bacilli stains, magnified at ×1,000, showing oocysts of Cryptosporidium spp. measuring approximately 4.62 µm. (B) Immunofluorescence staining, magnified at ×400, revealing oocysts of Cryptosporidium spp. measuring 4.40 µm. This figure appears in color at www.ajtmh.org.
See this image and copyright information in PMC

References

    1. Florescu DF, Sandkovsky U, 2016. Cryptosporidium infection in solid organ transplantation. World J Transplant 6: 460–471. - PMC - PubMed
    1. Mahmoudi MR, Ongerth JE, Karanis P, 2017. Cryptosporidium and cryptosporidiosis: the Asian perspective. Int J Hyg Environ Health 220: 1098–1109. - PubMed
    1. Torgerson PR, et al. 2015. World Health Organization estimates of the global and regional disease burden of 11 foodborne parasitic diseases, 2010: a data synthesis. PLoS Med 12: e1001920. - PMC - PubMed
    1. Laude A, et al. 2016. Is real-time PCR-based diagnosis similar in performance to routine parasitological examination for the identification of Giardia intestinalis, Cryptosporidium parvum/Cryptosporidium hominis and Entamoeba histolytica from stool samples? Evaluation of a new commercial multiplex PCR assay and literature review. Clin Microbiol Infect 22: 190.e1–190.e8. - PubMed
    1. Freeman K, Tsertsvadze A, Taylor-Phillips S, McCarthy N, Mistry H, Manuel R, Mason J, 2017. Agreement between gastrointestinal panel testing and standard microbiology methods for detecting pathogens in suspected infectious gastroenteritis: test evaluation and meta-analysis in the absence of a reference standard. PLoS One 12: e0173196. - PMC - PubMed

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