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. 2018 Nov 19;47(4):402-403.
doi: 10.1016/j.devcel.2018.11.003.

What Doesn't Kill You Makes You Stronger

Andrea K H Stavoe  1 , Erika L F Holzbaur  2
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What Doesn't Kill You Makes You Stronger

Andrea K H Stavoe et al. Dev Cell. .
Free article

Abstract

The microtubule-severing proteins spastin and katanin were long thought to destabilize microtubules. Recent work demonstrates that these enzymes inflict nano-damage on the microtubule lattice that is then rapidly repaired by new GTP-tubulin incorporation, for a net stabilization of the polymer, a process that has implications for neurodegenerative disease.

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