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. 2018 Nov;23(46):1800590.
doi: 10.2807/1560-7917.ES.2018.23.46.1800590.

Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak

Le Nguyen Thanh Nhan  1 , Nguyen Thi Thu Hong  2 , Le Nguyen Truc Nhu  2 , Lam Anh Nguyet  2 , Nguyen Thi Han Ny  2 , Tran Tan Thanh  2 , Do Duong Kim Han  2 , Hoang Minh Tu Van  2 , C Louise Thwaites  2   3 , Tran Tinh Hien  2   3 , Phan Tu Qui  4 , Pham Van Quang  1 , Ngo Ngoc Quang Minh  1 , H Rogier van Doorn  2   3 , Truong Huu Khanh  1 , Nguyen Van Vinh Chau  4 , Guy Thwaites  2   3 , Nguyen Thanh Hung  1 , Le Van Tan  2
Affiliations

Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak

Le Nguyen Thanh Nhan et al. Euro Surveill. 2018 Nov.

Abstract

Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011-12 among susceptible young children raises concern of another impending severe outbreak.

Keywords: Enteroviruses; Vietnam; enterovirus A71; foot and mouth disease; hand.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Monthly distribution of HFMD cases and HFMD cases with severe disease admitted to Children’s Hospital 1, Vietnam, January–September 2018 (n = 2,283)
Figure 2
Figure 2
Monthly distribution of clinical HFMD cases, including those who were PCR positive for EV-A71 or non-EV-A71 EVs, and clinical cases with severe HFMD enrolled in the study, Vietnam, January–September 2018 (n = 86 patients)
See this image and copyright information in PMC

References

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