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Review
. 2019 Jan;145(1):213-221.
doi: 10.1007/s00432-018-2792-4. Epub 2018 Nov 20.

Surgical staging in endometrial cancer

Maria Luisa Gasparri  1   2   3 , Donatella Caserta  4 , Pierluigi Benedetti Panici  5 , Andrea Papadia  6 , Michael D Mueller  6
Affiliations
Review

Surgical staging in endometrial cancer

Maria Luisa Gasparri et al. J Cancer Res Clin Oncol. 2019 Jan.

Abstract

In several malignancies, it has been demonstrated that the lymph nodal status is the most important pathologic factor affecting prognosis and giving the indication to further adjuvant treatment. The surgical assessment of the lymph nodal status in endometrial cancer is debated since 30 years. Recently, the sentinel lymph node mapping is rapidly gaining clinical acceptance in endometrial cancer. The adoption of Indocyanine Green as a safe and user friendly tracer for sentinel lymph node mapping increased the speed to which this procedure is getting applied in clinical practice. As a consequence of this rapid growth, several fundamental questions have been raised and are still debatable. In this manuscript, we discuss the importance of a known pathological lymph nodal status, the technique of the sentinel lymph node mapping with the reported false negative rates and detection rates according to the different tracers adopted, and the clinical scenarios in which a sentinel lymph node mapping could be employed.

Keywords: Endometrial cancer; Fluorescence; Indocyanine green; Laparoscopy; Sentinel lymph node mapping.

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Conflict of interest statement

The authors declare to have no conflict of interest.

Figures

Fig. 1
Fig. 1
Landmark studies and steps in the surgical staging of endometrial cancer. LND lymphadenectomy, SNL sentinel lymph node, PPALND pelvic and paraaortic lymphadenectomy, ICG indocyanine green
Fig. 2
Fig. 2
Figural depicted performance of frozen section of the uterus versus sentinel node lymph node mapping in identifying low-risk endometrial cancer patients with lymph nodal metastases
See this image and copyright information in PMC

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