Updates on the pathogenesis of advanced lung cancer-induced cachexia

doi:10.1111/1759-7714.12910

Review

. 2019 Jan;10(1):8-16.

doi: 10.1111/1759-7714.12910. Epub 2018 Nov 20.

Updates on the pathogenesis of advanced lung cancer-induced cachexia

Ruifang Zhu¹, Zhihong Liu², Ran Jiao¹, Chichen Zhang³, Qi Yu³, Shifan Han¹, Zhiguang Duan¹

Affiliations

¹ School of Nursing, Shanxi Medical University, Taiyuan, China.
² Department of Respiratory and Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.
³ School of Management, Shanxi Medical University, Taiyuan, China.

PMID: 30461213
PMCID: PMC6312840
DOI: 10.1111/1759-7714.12910

Review

Updates on the pathogenesis of advanced lung cancer-induced cachexia

Ruifang Zhu et al. Thorac Cancer. 2019 Jan.

. 2019 Jan;10(1):8-16.

doi: 10.1111/1759-7714.12910. Epub 2018 Nov 20.

Authors

Ruifang Zhu¹, Zhihong Liu², Ran Jiao¹, Chichen Zhang³, Qi Yu³, Shifan Han¹, Zhiguang Duan¹

Affiliations

¹ School of Nursing, Shanxi Medical University, Taiyuan, China.
² Department of Respiratory and Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.
³ School of Management, Shanxi Medical University, Taiyuan, China.

PMID: 30461213
PMCID: PMC6312840
DOI: 10.1111/1759-7714.12910

Abstract

Advanced lung cancer is becoming a chronic disease threatening human life and health. Cachexia has been recognized as the most common problem associated with advanced lung cancer. Lung cancer-induced cachexia seriously affects patients' quality of life. The present article summarizes the pathogenesis of advanced lung cancer-induced cachexia from three aspects: anorexia, cytokines, and energy and metabolic abnormalities. In addition, the present article proposes corresponding nursing measures based on cachexia pathogenesis to improve the quality of life and survival rate of cachectic patients with advanced lung cancer by combining continuously advancing treatment regimens and effective nursing. The present article also provides references for healthcare professionals when administering related treatments and nursing care.

Keywords: Cachexia; lung cancer; nursing; pathogenesis; therapeutics.

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References

1. Argiles JM, Lopez‐Soriano FJ, Busquets S. Mechanisms and treatment of cancer cachexia. Nutr Metab Cardiovasc Dis 2012; 23: s19–24. - PubMed
1. Consul N, Guo X, Coker C et al Monitoring metastasis and cachexia in a patient with breast cancer: A case study. Clin Med Insights Oncol 2016; 10: 83–94. - PMC - PubMed
1. Aoyagi T, Terracina KP, Raza A, Matsubara H, Takabe K. Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol 2015; 7: 17–29. - PMC - PubMed
1. Kimura M, Naito T, Kenmotsu H et al Prognostic impact of cancer cachexia in patients with advanced non‐small cell lung cancer. Support Care Cancer 2015; 23: 1699–708. - PubMed
1. Fortunati N, Manti R, Birocco N et al Pro‐inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio‐humoral profile of early cachexia in lung cancer patients. Oncol Rep 2007; 18: 1521–7. - PubMed

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[1] Argiles JM, Lopez‐Soriano FJ, Busquets S. Mechanisms and treatment of cancer cachexia. Nutr Metab Cardiovasc Dis 2012; 23: s19–24. - PubMed

[2] Argiles JM, Lopez‐Soriano FJ, Busquets S. Mechanisms and treatment of cancer cachexia. Nutr Metab Cardiovasc Dis 2012; 23: s19–24. - PubMed

[3] Consul N, Guo X, Coker C et al Monitoring metastasis and cachexia in a patient with breast cancer: A case study. Clin Med Insights Oncol 2016; 10: 83–94. - PMC - PubMed

[4] Consul N, Guo X, Coker C et al Monitoring metastasis and cachexia in a patient with breast cancer: A case study. Clin Med Insights Oncol 2016; 10: 83–94. - PMC - PubMed

[5] Aoyagi T, Terracina KP, Raza A, Matsubara H, Takabe K. Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol 2015; 7: 17–29. - PMC - PubMed

[6] Aoyagi T, Terracina KP, Raza A, Matsubara H, Takabe K. Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol 2015; 7: 17–29. - PMC - PubMed

[7] Kimura M, Naito T, Kenmotsu H et al Prognostic impact of cancer cachexia in patients with advanced non‐small cell lung cancer. Support Care Cancer 2015; 23: 1699–708. - PubMed

[8] Kimura M, Naito T, Kenmotsu H et al Prognostic impact of cancer cachexia in patients with advanced non‐small cell lung cancer. Support Care Cancer 2015; 23: 1699–708. - PubMed

[9] Fortunati N, Manti R, Birocco N et al Pro‐inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio‐humoral profile of early cachexia in lung cancer patients. Oncol Rep 2007; 18: 1521–7. - PubMed

[10] Fortunati N, Manti R, Birocco N et al Pro‐inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio‐humoral profile of early cachexia in lung cancer patients. Oncol Rep 2007; 18: 1521–7. - PubMed

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Updates on the pathogenesis of advanced lung cancer-induced cachexia

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Updates on the pathogenesis of advanced lung cancer-induced cachexia

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