Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Oct;62(5):530-536.
doi: 10.20945/2359-3997000000073.

Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial

Francisco Zacaron Werneck  1 , Emerson Filipino Coelho  1 , Saulo Peters Almas  2 , Marília Mendes do Nascimento Garcia  3 , Heloina Lamha Machado Bonfante  4 , Jorge Roberto Perrout de Lima  3 , Patrícia Dos Santos Vigário  5 , Míriam Raquel Meira Mainenti  6 , Patrícia de Fátima Dos Santos Teixeira  2 , Mário Vaisman  2
Affiliations
Randomized Controlled Trial

Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial

Francisco Zacaron Werneck et al. Arch Endocrinol Metab. 2018 Oct.

Abstract

Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training.

Subjects and methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL. In the second phase, a randomized clinical trial was conducted where only women with sHT were randomly divided into two groups: sHT-Tr (n = 10) - participants that performed an exercise program - and sHT-Sed (n = 10) - controls. Exercise training consisted of 60 minutes of aerobic activities (bike and treadmill), three times a week, for 16 weeks. The HRQoL was assessed by the SF-36 questionnaire in the early and at the end of four months.

Results: Women with sHT had lower scores on functional capacity domain in relation to the euthyroid ones (770 ± 23.0 vs. 88.8 ± 14.6; p = 0.020). The sHT-Tr group improved functional capacity, general health, emotional aspects, mental and physical component of HRQoL after training period, while the sHT-Sed group showed no significant changes.

Conclusion: After 16 weeks of aerobic exercise training, there were remarkable improvements in HRQoL in women with sHT.

PubMed Disclaimer

References

    1. Hoermann R, Midgley JEM, Larisch R, Dietrich JW. Recent advances in thyroid hormone regulation: toward a new paradigm for optimal diagnosis and treatment. Front Endocrinol (Lausanne). 2017;8:364. - PMC - PubMed
    1. Surks MI1, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004;291(2):228-38. - PubMed
    1. Sgarbi JA, Teixeira PFS, Maciel LMZ, Mazeto GMFS, Vaisman M, Montenegro Junior RM, et al. Consenso brasileiro para a abordagem clínica e tratamento do hipotireoidismo subclínico em adultos: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia. Arq Bras Endocrinol Metabol. 2013;57(3):166-83. - PubMed
    1. Cooper DS, Biondi B. Subclinical thyroid disease. Lancet. 2012;379(9821):1142-54. - PubMed
    1. Gulseren S, Gulseren L, Hekimsoy Z, Cetinay P Ozen C,Tokatlioglu B. Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction. Arch Med Res. 2006;37(1):133-9. - PubMed

Publication types

MeSH terms