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Comment
. 2018 Nov 20;49(5):783-785.
doi: 10.1016/j.immuni.2018.11.005.

Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation

Simon Pascual-Gil  1 , Slava Epelman  2
Affiliations
Free article
Comment

Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation

Simon Pascual-Gil et al. Immunity. .
Free article

Abstract

Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in mouse models.

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  • Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.
    Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J. Braza MS, et al. Immunity. 2018 Nov 20;49(5):819-828.e6. doi: 10.1016/j.immuni.2018.09.008. Epub 2018 Nov 6. Immunity. 2018. PMID: 30413362 Free PMC article.