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. 2018 Nov 20;49(5):796-798.
doi: 10.1016/j.immuni.2018.11.002.

Are Neuropeptide-Reactive T Cells behind Narcolepsy?

M Elizabeth Deerhake  1 , William E Barclay  1 , Mari L Shinohara  2
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Are Neuropeptide-Reactive T Cells behind Narcolepsy?

M Elizabeth Deerhake et al. Immunity. .
Free article

Abstract

Researchers have previously hypothesized autoimmune origins for narcolepsy on the basis of its strong genetic association with an MHC class II allele. In a recent issue of Nature, Latorre et al. (2018) discovered that narcolepsy patients had autoreactive T cells specific to the neuronal antigen hypocretin, providing more evidence of the potential immune origin of the disease.

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