Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine
- PMID: 30463587
- PMCID: PMC6249727
- DOI: 10.1186/s13287-018-1067-y
Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine
Abstract
Stem cells (SCs) play an important role in autologous and even allogenic applications. Menstrual blood discharge has been identified as a valuable source of SCs which are referred to as menstrual blood-derived stem cells (MenSCs). Compared to SCs from bone marrow and adipose tissues, MenSCs come from body discharge and obtaining them is non-invasive to the body, they are easy to collect, and there are no ethical concerns. There is, hence, a growing interest in the functions of MenSCs and their potential applications in regenerative medicine. This review presents recent progress in research into MenSCs and their potential application. Clinical indications of using MenSCs for various regenerative medicine applications are emphasized, and future research is recommended to accelerate clinical applications of MenSCs.
Keywords: Menstrual blood; Menstrual blood-derived stem cells; Regenerative medicine.
Conflict of interest statement
Ethics approval and consent to participate
Not applicable.
Consent for publication
All authors consent to the publication of this manuscript.
Competing interests
The authors declare that they have no competing interests.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Similar articles
-
Comparative evaluation of cardiac markers in differentiated cells from menstrual blood and bone marrow-derived stem cells in vitro.Mol Biotechnol. 2014 Dec;56(12):1151-62. doi: 10.1007/s12033-014-9795-4. Mol Biotechnol. 2014. PMID: 25189461
-
Proliferation and chondrogenic differentiation potential of menstrual blood- and bone marrow-derived stem cells in two-dimensional culture.Int J Hematol. 2012 May;95(5):484-93. doi: 10.1007/s12185-012-1067-0. Epub 2012 Apr 15. Int J Hematol. 2012. PMID: 22527849
-
Comparative capability of menstrual blood versus bone marrow derived stem cells in neural differentiation.Mol Biol Rep. 2017 Feb;44(1):169-182. doi: 10.1007/s11033-016-4095-7. Epub 2016 Dec 15. Mol Biol Rep. 2017. PMID: 27981446
-
The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine.Stem Cell Res Ther. 2019 Jan 3;10(1):1. doi: 10.1186/s13287-018-1105-9. Stem Cell Res Ther. 2019. PMID: 30606242 Free PMC article. Review.
-
Menstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases.Stem Cell Res Ther. 2019 Dec 21;10(1):406. doi: 10.1186/s13287-019-1503-7. Stem Cell Res Ther. 2019. PMID: 31864423 Free PMC article. Review.
Cited by
-
Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion.World J Stem Cells. 2020 May 26;12(5):368-380. doi: 10.4252/wjsc.v12.i5.368. World J Stem Cells. 2020. PMID: 32547685 Free PMC article.
-
Single-cell RNA sequencing reveals reduced intercellular adhesion molecule crosstalk between activated hepatic stellate cells and neutrophils alleviating liver fibrosis in hepatitis B virus transgenic mice post menstrual blood-derived mesenchymal stem cell transplantation.MedComm (2020). 2024 Jul 22;5(8):e654. doi: 10.1002/mco2.654. eCollection 2024 Aug. MedComm (2020). 2024. PMID: 39040848 Free PMC article.
-
Amelioration of female menopausal syndrome by intravenous administration of autologous menstrual blood-derived stem cells.Regen Ther. 2025 Mar 26;29:192-201. doi: 10.1016/j.reth.2025.03.009. eCollection 2025 Jun. Regen Ther. 2025. PMID: 40225052 Free PMC article.
-
Menstrual blood-derived mesenchymal stem cells combined with collagen I gel as a regenerative therapeutic strategy for degenerated disc after discectomy in rats.Stem Cell Res Ther. 2024 Mar 13;15(1):75. doi: 10.1186/s13287-024-03680-w. Stem Cell Res Ther. 2024. PMID: 38475906 Free PMC article.
-
Menstrual Blood as a Diagnostic Specimen for Human Papillomavirus Genotyping and Genital Tract Infection Using Next-Generation Sequencing as a Novel Diagnostic Tool.Diagnostics (Basel). 2024 Mar 25;14(7):686. doi: 10.3390/diagnostics14070686. Diagnostics (Basel). 2024. PMID: 38611599 Free PMC article.
References
-
- Rossignoli F, Caselli A, Grisendi G, Piccinno S, Burns JS, Murgia A, Veronesi E, Loschi P, Masini C, Conte P, Paolucci P, Horwiz EM, Dominici M. Isolation, characterization, and transduction of endometrial decidual tissue multipotent mesenchymal stromal/stem cells from menstrual blood. Biomed Res Int. 2013;2013:901821. doi: 10.1155/2013/901821.. - DOI - PMC - PubMed
-
- Wu X, Luo Y, Chen J, Pan R, Xiang B, Du X, Xiang L, Shao J, Xiang C. Transplantation of human menstrual blood progenitor cells improves hyperglycemia by promoting endogenous progenitor differentiation in type 1 diabetic mice. Stem Cells Dev. 2014;23:1245–1257. doi: 10.1089/scd.2013.0390. - DOI - PMC - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical