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Multicenter Study
. 2019 Jan 30;57(2):e01505-18.
doi: 10.1128/JCM.01505-18. Print 2019 Feb.

Invasive Infections Due to Trichosporon: Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China

Li-Na Guo #  1   2 , Shu-Ying Yu #  1   2   3 , Po-Ren Hsueh  4 , Abdullah M S Al-Hatmi  5   6   7 , Jacques F Meis  6   8 , Ferry Hagen  5   8 , Meng Xiao  1   2 , He Wang  1   2 , Cinzia Barresi  9 , Meng-Lan Zhou  1   2   3 , G Sybren de Hoog  10   6 , Ying-Chun Xu  11   2
Affiliations
Multicenter Study

Invasive Infections Due to Trichosporon: Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China

Li-Na Guo et al. J Clin Microbiol. .

Abstract

A total of 133 clinical Trichosporon isolates were collected in the National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program in 2009 to 2016. Accurate identification was performed by sequencing of the intergenic spacer 1 (IGS1) region. Among these isolates, Trichosporon asahii (108 isolates [81.2%]) was the leading species, followed by Trichosporon dermatis (7 isolates [5.3%]), Trichosporon asteroides (5 isolates [3.8%]), Trichosporon inkin (5 isolates [3.8%]), Trichosporon dohaense (3 isolates [2.3%]), and 1 isolate (0.7%) each of Trichosporon faecale, Trichosporon jirovecii, Trichosporon mucoides, Trichosporon coremiiforme, and Trichosporon montevideense Both the Vitek mass spectrometry (MS) (bioMérieux, Marcy l'Etoile, France) and Bruker Biotyper MS (Bruker Daltonics GmbH, Germany) platforms gave high levels (>97.5%) of correct identification when the species were present in the database. The geometric mean (GM) of amphotericin B MICs for T. asahii was 2-fold higher than that for non-asahii Trichosporon High fluconazole MICs (≥8 μg/ml) were observed for 25% of T. asahii isolates (27/108 isolates) and 16% of non-asahii Trichosporon (4/25 isolates) isolates. Itraconazole MICs were ≤0.5 μg/ml for 89.5% of the isolates. Voriconazole was the most potent antifungal agent in vitro, with a GM of 0.09 μg/ml. Genotyping of the isolates using IGS1 sequence alignment revealed that genotype 1 was most common (41.7%), followed by genotype 4 (31.5%), genotype 3 (23.1%), genotype 5 (0.9%), genotype 6 (0.9%), and genotype 7 (1.8%). Our data on species distribution, genotypes, and antifungal susceptibilities may contribute to a better understanding of the epidemiology of invasive Trichosporon infections throughout China.

Keywords: China; Trichosporon; genotype; invasive infection; susceptibility.

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Figures

FIG 1
FIG 1
Regional distribution of 133 cases of invasive infections caused by Trichosporon species that occurred in China in 2009 to 2016.
See this image and copyright information in PMC

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