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Comment
. 2019 Jan;9(1):7-8.
doi: 10.1158/2159-8290.CD-NB2018-155. Epub 2018 Nov 21.

Anti-CD47 Agent Boosts Macrophage Activity in NHL

No authors listed
Comment

Anti-CD47 Agent Boosts Macrophage Activity in NHL

No authors listed. Cancer Discov. 2019 Jan.

Abstract

The anti-CD47 drug Hu5F9-G4, also known as 5F9, in combination with the anti-CD20 therapy rituximab, may be a promising treatment for some forms of non-Hodgkin lymphoma because it allows macrophages to recognize and attack cancer cells. In a phase Ib trial testing the combination, patients with relapsed/refractory diffuse large B-cell lymphoma or follicular lymphoma had an objective response rate of 50% and few side effects.

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Comment on

  • CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma.
    Advani R, Flinn I, Popplewell L, Forero A, Bartlett NL, Ghosh N, Kline J, Roschewski M, LaCasce A, Collins GP, Tran T, Lynn J, Chen JY, Volkmer JP, Agoram B, Huang J, Majeti R, Weissman IL, Takimoto CH, Chao MP, Smith SM. Advani R, et al. N Engl J Med. 2018 Nov 1;379(18):1711-1721. doi: 10.1056/NEJMoa1807315. N Engl J Med. 2018. PMID: 30380386 Free PMC article. Clinical Trial.

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