Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Dec;68(12):2257-2260.
doi: 10.1136/gutjnl-2018-317561. Epub 2018 Nov 21.

Gut microbiota dynamics and uraemic toxins: one size does not fit all

Marie Joossens #  1   2 , Karoline Faust #  1 , Tessa Gryp #  1   3   4 , Anh Thi Loan Nguyen  5 , Jun Wang  1   2   6 , Sunny Eloot  3 , Eva Schepers  3 , Annemieke Dhondt  3 , Anneleen Pletinck  3 , Sara Vieira-Silva  1   2 , Gwen Falony  1   2 , Mario Vaneechoutte  4 , Raymond Vanholder  3 , Wim Van Biesen  3 , Geert Roger Bertrand Huys  1   2 , Jeroen Raes #  1   2 , Griet Glorieux #  3
Affiliations
Comment

Gut microbiota dynamics and uraemic toxins: one size does not fit all

Marie Joossens et al. Gut. 2019 Dec.
No abstract available

Keywords: intestinal bacteria; intestinal microbiology.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Main covariates of the faecal microbiota composition of patients with ESKD. Final selected numeric metadata in addition to top 10 taxa correlating with PCoA eigenvectors (ie, with overall community composition). Biplot computed with Bray Curtis dissimilarity on rarefied read counts. Length of arrows reflects correlation with overall community composition. Per patient, a different colour is used. CMPF, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; ESKD, end-stage kidney disease.
Figure 2
Figure 2
Associations between p-cresyl conjugates and indoxyl sulfate and intestinal microbiota, subcohort analysis. Faecal microbiota composition of samples with highest p-cresyl (pCS+pCG) and lowest IxS concentrations (group 1 in red) was compared with that of samples with highest IxS and lowest pC concentrations (group 2 in green). (A): The top 15 taxa with the largest difference between the two groups. Group-specific taxon proportion vectors were obtained by fitting the Dirichlet Multinomial distribution to each sample set (using R package HMP, function DM.MoM). The HMP package function Xmcupo.sevsample (Generalised Wald-type statistics) was used to compute whether the difference between the two taxon proportion vectors (highest pC/lowest IxS vs lowest pC/highest IxS) was significant (p<0.0001). (B) Effect sizes of genera that differed significantly between the datasets using LDA effect size (LEfSe). The length of the bar represents a log10 transformed LDA score. The colours represent in which group those taxa were found to be more abundant compared with the other group. Absolute values of the effect sizes should be used to interpret the scale of the difference between both groups. LDA, linear discriminant analysis.
See this image and copyright information in PMC

Comment on

References

    1. Chu H, Duan Y, Yang L, et al. . Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease. Gut 2019;68:359–70. 10.1136/gutjnl-2018-316307 - DOI - PubMed
    1. Vaziri ND, Wong J, Pahl M, et al. . Chronic kidney disease alters intestinal microbial flora. Kidney Int 2013;83:308–15. 10.1038/ki.2012.345 - DOI - PubMed
    1. Vanholder R, Glorieux G. Gut-derived metabolites and chronic kidney disease: the Forest (F)or the trees? Clin J Am Soc Nephrol 2018;13:1311–3. 10.2215/CJN.08200718 - DOI - PMC - PubMed
    1. Anders HJ, Andersen K, Stecher B. The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. Kidney Int 2013;83:1010–6. 10.1038/ki.2012.440 - DOI - PubMed
    1. Barreto FC, Barreto DV, Liabeuf S, et al. . Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 2009;4:1551–8. 10.2215/CJN.03980609 - DOI - PMC - PubMed