Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov 1:11:7709-7714.
doi: 10.2147/OTT.S175825. eCollection 2018.

The clinical feasibility of flexible bronchoscopy interventional therapy in patients with central airway stenosis and respiratory failure caused by malignancy

Jiwang Wang  1 , Yang Yang  2 , Wangjian Zha  1 , Xiuwei Zhang  2
Affiliations

The clinical feasibility of flexible bronchoscopy interventional therapy in patients with central airway stenosis and respiratory failure caused by malignancy

Jiwang Wang et al. Onco Targets Ther. .

Abstract

Objective: The aim of this study was to investigate the clinical effects and feasibility of using flexible bronchoscopy intervention in cases of malignancy that causes central airway stenosis and respiratory failure.

Methods: The clinical data of patients who were admitted to the Department of Respiratory Medicine at the First Affiliated Hospital of Nanjing Medical University and underwent treatment of a malignant tumor with central airway stenosis and respiratory failure by flexible bronchos-copy from February 2010 to May 2013 were analyzed using a retrospective method. The age, gender, location, extent of airway stenosis, interventional therapy, efficacy, and complications for 12 patients were collected and analyzed using the SPSS 13.0 software.

Results: After interventional therapy, the dyspnea index for all the patients improved signifi-cantly, and compared with before treatment, the difference was statistically significant (t=13.40, P<0.01). Eleven patients with respiratory failure were corrected, and only one patient was treated via tracheal intubation with mechanical ventilation. There were no severe complications, such as massive hemorrhaging or cardiac arrest in any case.

Conclusion: Flexible bronchoscopy interventional treatment for central airway stenosis and respiratory failure caused by malignant tumors is an effective and safe method. It should be applied in clinical work.

Keywords: central airway; flexible bronchoscopy; interventional treatment; malignant tumors; respiratory failure.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Three-dimensional imaging of the airway showing significant stenosis in the middle of the trachea and atelectasis in the lower left part of the lung.
Figure 2
Figure 2
Flexible bronchoscopy showed obstructive stenosis of the trachea.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Wahidi MM, Herth FJ, Ernst A. State of the art: interventional pulmonol-ogy. Chest. 2007;131(1):261–274. - PubMed
    1. Gorden JA, Ernst A. Endoscopic management of central airway obstruction. Semin Thorac Cardiovasc Surg. 2009;21(3):263–273. - PubMed
    1. Cosano Povedano A, Muñoz Cabrera L, Cosano Povedano FJ, et al. Endoscopic treatment of central airway stenosis: five years’ experience. Arch Bronconeumol. 2005;41(6):322–327. Spanish. - PubMed
    1. Zhang H, Wang GF. Reatment of malignant central airway stenosis. Chin J Front Med Sci. 2014;6(2):19–21.
    1. Li LY. Etiology and pathophysiological changes of central airway steno-sis. Chin J Tubercul Respir Dis. 2003;26(7):387–388.