Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Oct 26:10:4653-4667.
doi: 10.2147/CMAR.S178567. eCollection 2018.

Celecoxib in breast cancer prevention and therapy

Jieqing Li  1   2 , Qiongyu Hao  2 , Wei Cao  2   3 , Jaydutt V Vadgama  2   4 , Yong Wu  2   4
Affiliations
Review

Celecoxib in breast cancer prevention and therapy

Jieqing Li et al. Cancer Manag Res. .

Abstract

Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively associated with the reduced risk of the occurrence and progression of a number of types of cancer, particularly breast cancer. This observation is also substantiated by various meta-analyses. Clinical trials have been implemented on integration treatment of celecoxib and shown encouraging results. Celecoxib could be treated as a potential candidate for antitumor agent. There are, nonetheless, some unaddressed questions concerning the precise mechanism underlying the anticancer effect of celecoxib as well as its activity against different types of cancer. In this review, we discuss different mechanisms of anticancer effect of celecoxib as well as preclinical/clinical results signifying this beneficial effect.

Keywords: COX-2; breast cancer; celecoxib; inflammation.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The identified mechanisms of anticancer effect of celecoxib. Abbreviations: EP1, prostaglandin E2 receptor 1; MMP, matrix metalloproteinase; NK, natural killer; PEG2, prostaglandin E2; PGH2, prostaglandin E2; VEGF, vascular endothelial growth factor.
See this image and copyright information in PMC

References

    1. Evans DG, Howell A. Breast cancer risk-assessment models. Br Cancer Res. 2007;9(5):213. - PMC - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. 2018. - PubMed
    1. Rayburn E, Ezell SJ, Zhang R. Anti-Inflammatory Agents for Cancer Therapy. Mol Cell Pharmacol. 2009;1(1):29–43. - PMC - PubMed
    1. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860–867. - PMC - PubMed
    1. Allen MD, Jones LJ. The role of inflammation in progression of breast cancer: Friend or foe? (Review) Int J Oncol. 2015;47(3):797–805. - PubMed