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Case Reports
. 2018 Oct;8(4):e332-e334.
doi: 10.1055/s-0038-1675335. Epub 2018 Nov 20.

Heterogeneous Presentation of Neonatal Hemochromatosis in Dichorionic Twins

Yee Yuet Chee  1 , Siu Chun Mabel Wong  1 , Ming Sum Rosanna Wong  1
Affiliations
Case Reports

Heterogeneous Presentation of Neonatal Hemochromatosis in Dichorionic Twins

Yee Yuet Chee et al. AJP Rep. 2018 Oct.

Abstract

Acute liver failure (ALF) in neonates is rare. Although the incidence is reported to be rare, neonatal hemochromatosis (NH) has to be considered as one of the causes of neonatal ALF. We present a pair of dichorionic twin who had a diverse clinical presentation of NH. One twin passed away despite medical treatment with exchange transfusion and intravenous immunoglobulin (IVIg), whereas the other twin suffered from only mildly deranged liver function, which normalized spontaneously. Early identification of liver failure and clinical awareness of this disease entity are essential to its timely diagnosis and treatment. Antenatal management using IVIg prevents the recurrence of NH in subsequent pregnancies.

Keywords: gestational alloimmune liver disease; liver failure; neonatal hemochromatosis.

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Conflict of interest statement

Conflicts of Interest All contributing authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Liver biopsy showing hepatocellular siderosis (left) and abnormal iron deposition in salivary gland (right), demonstrating iron in blue by Perl's stain.
See this image and copyright information in PMC

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