Review
doi: 10.1016/0167-4943(88)90030-1.
E-rosettes in aging: meta-analysis of the literature
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- PMID: 3046535
- DOI: 10.1016/0167-4943(88)90030-1
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Review
E-rosettes in aging: meta-analysis of the literature
Arch Gerontol Geriatr.
1988 Jun.
Abstract
In this meta-analysis of the literature, it is affirmed that aging is associated with a small but significant decline in peripheral E-rosette-forming cells while high affinity E-rosettes (active or early rosettes) increase. The author speculates that this differential age effect may reflect the abnormal capping behaviour of E-rosettes or a change in the cell surface charge properties. A type II error is a common trait of the reviewed studies and could well explain the great number of reports concluding that E-rosette-forming cells are unaltered in the elderly.
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