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Observational Study
. 2019 Feb;47(2):765-771.
doi: 10.1177/0300060518811009. Epub 2018 Nov 22.

Biochemical changes associated with temporomandibular disorders

Canser Yilmaz Demir  1 , Muhammet Eren Ersoz  1
Affiliations
Observational Study

Biochemical changes associated with temporomandibular disorders

Canser Yilmaz Demir et al. J Int Med Res. 2019 Feb.

Abstract

Objective: To assess vitamin D, parathyroid hormone, calcitonin, calcium, phosphorus and magnesium levels in patients with versus without temporomandibular disorders (TMDs).

Methods: This prospective observational study included patients with TMDs and age-matched healthy controls. TMDs were diagnosed via physical and radiologic examination, and serum levels of 25 (OH) vitamin D, parathyroid hormone, calcitonin, calcium, magnesium, and phosphorus were determined. The impact of age, sex and seasonal variations in serum 25 (OH) vitamin D levels was controlled by the inclusion of age, sex and date-matched control patients.

Results: The study included 100 patients, comprising 50 patients with TMDs and 50 control patients. No statistically significant between-group differences were found regarding age or sex. No statistically significant between-group differences were found in terms of serum 25 (OH) vitamin D, calcitonin, calcium, magnesium or phosphorus levels. Parathyroid hormone levels were statistically significantly higher in patients with TMDs versus healthy control patients.

Conclusion: In patients with temporomandibular disorders, increased parathyroid hormone levels in response to vitamin D deficiency was significantly more prominent. These data suggest that, in patients with temporomandibular disorders, vitamin D deficiency should be assessed and corrected.

Keywords: Temporomandibular joint disorders; calcitonin; calcium homeostasis; disc displacement; parathyroid hormone; subluxation; vitamin D.

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References

    1. Schiffman E, Ohrbach R, Truelove E, et al. Diagnostic criteria for temporomandibular disorders (DC/TMD) for clinical and research applications: recommendations of the International RDC/TMD Consortium Network and Orofacial Pain Special Interest Group. J Oral Facial Pain Headache 2014; 28: 6–27. - PMC - PubMed
    1. Al-Jundi MA, John MT, Setz JM, et al. Meta-analysis of treatment need for temporomandibular disorders in adult nonpatients. J Orofac Pain 2008; 22: 97–107. - PubMed
    1. De Leeuw R. Orofacial pain: guidelines for assessment, diagnosis and management. 4th ed Chicago, USA: Quintessence Publishing Co., 2008, pp.131–132.
    1. Takano H, Ariyoshi W, Kanno T, et al. Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders. Osteoarthritis Cartilage 2007; 15: 291–299. - PubMed
    1. Ding C, Cicuttini F, Parameswaran V, et al. Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort study. Arthritis Rheum 2009; 60: 1381–1389. - PubMed

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